LSP1 (red) expression in mouse endothelial cells is required for neutrophil transmigration.
Neutrophils must traverse the endothelial cell barrier to migrate out of blood vessels into inflamed or injured tissue. Transendothelial migration, once thought to be controlled primarily by the neutrophil, is now known to be a two-way street that requires active participation by both cell types. Endothelial cells respond to neutrophil adhesion by increasing their intracellular calcium levels and rearranging proteins that maintain the tight junctions between neighboring cells. The rearrangement of junctional proteins in endothelial cells ultimately causes them to retract from one another and allows the neutrophils to pass, although the signaling pathways involved are not completely understood.Leukocyte-specific protein 1 (LSP1) is...
