Mutational escape from CD8+ T cell immunity HCV evolution, from chimpanzees to man

Bowen , David G.; Walker , Christopher M.

doi:10.1084/jem.20050808

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Commentary| June 06 2005

Mutational escape from CD8⁺ T cell immunity : HCV evolution, from chimpanzees to man

David G. Bowen,

David G. Bowen

aD.G.B. and C.M.W. are at Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205.

bC.M.W. is at College of Medicine and Public Health, Ohio State University, Columbus, OH 43210.

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Christopher M. Walker

aD.G.B. and C.M.W. are at Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205.

bC.M.W. is at College of Medicine and Public Health, Ohio State University, Columbus, OH 43210.

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Author and Article Information

David G. Bowen

aD.G.B. and C.M.W. are at Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205.

bC.M.W. is at College of Medicine and Public Health, Ohio State University, Columbus, OH 43210.

Christopher M. Walker

aD.G.B. and C.M.W. are at Center for Vaccines and Immunity, Columbus Children's Research Institute, Columbus, OH 43205.

bC.M.W. is at College of Medicine and Public Health, Ohio State University, Columbus, OH 43210.

CORRESPONDENCE C.M.W.: [email protected]

Online ISSN: 1540-9538

Print ISSN: 0022-1007

The Rockefeller University Press

2005

J Exp Med (2005) 201 (11): 1709–1714.

https://doi.org/10.1084/jem.20050808

The mechanisms by which the hepatitis C virus (HCV) establishes persistence are not yet fully understood. Previous chimpanzee and now human studies suggest that mutations within MHC class I–restricted HCV epitopes might contribute to viral escape from cytotoxic T lymphocyte (CTL) responses. However, there are several outstanding questions regarding the role of escape mutations in viral persistence and their fate in the absence of immune selection pressure.

The Rockefeller University Press

2005

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Mutational escape from CD8⁺ T cell immunity : HCV evolution, from chimpanzees to man