A role for immunoglobulin E and its high affinity receptor (FcεRI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized FcεRI (hFcεRI), with a cell distribution similar to that in humans, to FcεRI-deficient animals. In hFcεRI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFcεRI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas FcεRI-deficient animals were protected from colitis, demonstrating that FcεRI can affect the onset of intestinal inflammation.
Skip Nav Destination
Article navigation
1 January 2001
Article|
December 27 2000
Role of the High Affinity Immunoglobulin E Receptor in Bacterial Translocation and Intestinal Inflammation
David Dombrowicz,
David Dombrowicz
aInstitut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
Search for other works by this author on:
Sophie Nutten,
Sophie Nutten
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Search for other works by this author on:
Pierre Desreumaux,
Pierre Desreumaux
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Search for other works by this author on:
Christel Neut,
Christel Neut
dFaculty of Pharmacy, University of Lille II, 59045 Lille, France
Search for other works by this author on:
Gérard Torpier,
Gérard Torpier
bInstitut National de la Sante et de la Recherche Medicale U325, Institut Pasteur de Lille, 59019 Lille, France
Search for other works by this author on:
Marc Peeters,
Marc Peeters
eDepartment of Gastroenterology, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Search for other works by this author on:
Jean-Frédéric Colombel,
Jean-Frédéric Colombel
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Search for other works by this author on:
Monique Capron
Monique Capron
aInstitut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
Search for other works by this author on:
David Dombrowicz
aInstitut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
Sophie Nutten
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Pierre Desreumaux
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Christel Neut
dFaculty of Pharmacy, University of Lille II, 59045 Lille, France
Gérard Torpier
bInstitut National de la Sante et de la Recherche Medicale U325, Institut Pasteur de Lille, 59019 Lille, France
Marc Peeters
eDepartment of Gastroenterology, University Hospital Gasthuisberg, B-3000 Leuven, Belgium
Jean-Frédéric Colombel
cLaboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
Monique Capron
aInstitut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
D. Dombrowicz, S. Nutten, and P. Desreumaux contributed equally to this work.
Abbreviations used in this paper: CD, Crohn's disease; hFcεRI, human FcεRI; IBD, inflammatory bowel disease, MLN, mesenteric lymph node, RT, reverse transcription; SPF, specific pathogen-free; Tg, transgenic; TNBS, 2,4,6-tri-nitrobenzenesulfonic acid; WT, wild-type.
Received:
June 26 2000
Revision Requested:
November 16 2000
Accepted:
November 20 2000
Online ISSN: 1540-9538
Print ISSN: 0022-1007
© 2001 The Rockefeller University Press
2001
The Rockefeller University Press
J Exp Med (2001) 193 (1): 25–34.
Article history
Received:
June 26 2000
Revision Requested:
November 16 2000
Accepted:
November 20 2000
Citation
David Dombrowicz, Sophie Nutten, Pierre Desreumaux, Christel Neut, Gérard Torpier, Marc Peeters, Jean-Frédéric Colombel, Monique Capron; Role of the High Affinity Immunoglobulin E Receptor in Bacterial Translocation and Intestinal Inflammation. J Exp Med 1 January 2001; 193 (1): 25–34. doi: https://doi.org/10.1084/jem.193.1.25
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement