A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family, as receptors for APRIL. APRIL binds BCMA with higher affinity than TACI. A soluble form of BCMA, which inhibits the proliferative activity of APRIL in vitro, decreases tumor cell proliferation in nude mice. Growth of HT29 colon carcinoma cells is blocked when mice are treated once per week with the soluble receptor. These results suggest an important role for APRIL in tumorigenesis and point towards a novel anticancer strategy.
Article navigation
4 December 2000
Brief Definitive Report|
December 04 2000
A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth
Paul Rennert,
Paul Rennert
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Pascal Schneider,
Pascal Schneider
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Search for other works by this author on:
Teresa G. Cachero,
Teresa G. Cachero
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Jeffrey Thompson,
Jeffrey Thompson
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Luciana Trabach,
Luciana Trabach
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Sylvie Hertig,
Sylvie Hertig
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Search for other works by this author on:
Nils Holler,
Nils Holler
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Search for other works by this author on:
Fang Qian,
Fang Qian
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Colleen Mullen,
Colleen Mullen
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Kathy Strauch,
Kathy Strauch
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Jeffrey L. Browning,
Jeffrey L. Browning
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Christine Ambrose,
Christine Ambrose
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Search for other works by this author on:
Jürg Tschopp
Jürg Tschopp
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Search for other works by this author on:
Paul Rennert
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Pascal Schneider
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Teresa G. Cachero
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Jeffrey Thompson
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Luciana Trabach
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Sylvie Hertig
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Nils Holler
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
Fang Qian
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Colleen Mullen
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Kathy Strauch
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Jeffrey L. Browning
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Christine Ambrose
bDepartments of Molecular Genetics, Immunology, Inflammation, Cell Biology, and Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
Jürg Tschopp
aInstitute of Biochemistry, BIL Biomedical Research Center, University of Lausanne, CH-1066 Epalinges, Switzerland
P. Rennert and P. Schneider contributed equally to this work.
Received:
June 23 2000
Revision Requested:
September 29 2000
Accepted:
October 11 2000
Online ISSN: 1540-9538
Print ISSN: 0022-1007
© 2000 The Rockefeller University Press
2000
The Rockefeller University Press
J Exp Med (2000) 192 (11): 1677–1684.
Article history
Received:
June 23 2000
Revision Requested:
September 29 2000
Accepted:
October 11 2000
Citation
Paul Rennert, Pascal Schneider, Teresa G. Cachero, Jeffrey Thompson, Luciana Trabach, Sylvie Hertig, Nils Holler, Fang Qian, Colleen Mullen, Kathy Strauch, Jeffrey L. Browning, Christine Ambrose, Jürg Tschopp; A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth. J Exp Med 4 December 2000; 192 (11): 1677–1684. doi: https://doi.org/10.1084/jem.192.11.1677
Download citation file:
Sign in
Don't already have an account? Register
Suggested Content
Email alerts
Advertisement
