T cell-independent type 2 (TI-2), in contrast to T-dependent, antigens stimulate the production of murine IgG3. To investigate a possible role for cytokines in mediating the induction of this IgG subclass, we established an in vitro polyclonal model system for studying TI-2 antigen-mediated B cell activation by using dextran-conjugated anti-IgD antibody (alpha delta-dex). We demonstrate that interferon gamma (IFN-gamma) stimulates, and interleukin 4 inhibits, the expression of IgG3 by alpha delta-dexactivated cells. The production of IFN-gamma by non-T cells in response to bacterial products, possibly capsular polysaccharides, may provide an explanation underlying the ability of TI antigens, which are unable to directly stimulate T cell-derived cytokines to induce Ig isotype switching.
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1 May 1992
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May 01 1992
Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.
C M Snapper,
C M Snapper
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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T M McIntyre,
T M McIntyre
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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R Mandler,
R Mandler
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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L M Pecanha,
L M Pecanha
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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F D Finkelman,
F D Finkelman
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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A Lees,
A Lees
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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J J Mond
J J Mond
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
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C M Snapper
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
T M McIntyre
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
R Mandler
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
L M Pecanha
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
F D Finkelman
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
A Lees
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
J J Mond
Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1992) 175 (5): 1367–1371.
Citation
C M Snapper, T M McIntyre, R Mandler, L M Pecanha, F D Finkelman, A Lees, J J Mond; Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens.. J Exp Med 1 May 1992; 175 (5): 1367–1371. doi: https://doi.org/10.1084/jem.175.5.1367
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