Interleukin 1 (IL-1) plays a central role in the regulation of the body's response to infectious and inflammatory stimuli. Recent evidence has shown that human platelets express a cell associated form of this proinflammatory cytokine very rapidly following activation. Since one of the earliest events in inflammation is frequently the rapid adhesion of platelets to injured endothelium, it was of interest to determine whether platelets express IL-1 in a functionally relevant form that can alter the phenotype of human endothelial cells in vitro. Thrombin activated platelets induced significant expression of the adhesion molecule intercellular adhesion molecule 1, as well as secretion of the IL-1 inducible cytokines IL-6 and granulocyte macrophage colony stimulating factor by cultured human umbilical cord and saphenous vein endothelial cells. This was inhibited by prior treatment of the platelets with antibody specific for IL-1. These results suggest that platelet delivered IL-1 might initiate and regulate some of the earliest phases of the inflammatory response. An additional observation of interest was differential induction of endothelial leucocyte adhesion molecule 1 by activated platelets on saphenous vein but not umbilical vein but not umbilical vein endothelial cells, which suggests functional heterogeneity of the endothelial cells.
Skip Nav Destination
Article navigation
1 October 1991
Article|
October 01 1991
Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.
C M Hawrylowicz,
C M Hawrylowicz
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
Search for other works by this author on:
G L Howells,
G L Howells
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
Search for other works by this author on:
M Feldmann
M Feldmann
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
Search for other works by this author on:
C M Hawrylowicz
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
G L Howells
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
M Feldmann
Charing Cross Sunley Research Centre, Hammersmith, London, United Kingdom.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1991) 174 (4): 785–790.
Citation
C M Hawrylowicz, G L Howells, M Feldmann; Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production.. J Exp Med 1 October 1991; 174 (4): 785–790. doi: https://doi.org/10.1084/jem.174.4.785
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement