Irradiated malaria sporozoites can induce CD8+ T cells that are required for protection against infection. However, the parasite antigens targeted by this immune response are unknown. We have discovered a 16-amino acid epitope from the Plasmodium yoelii circumsporozoite (CS) protein that is recognized by cytotoxic T cells from immune mice. Lymphocytes stimulated with this peptide can kill P. yoelii liver stage parasites in vitro in an MHC-restricted, antigen-specific manner. Thus, epitopes from the CS protein are presented on the surface of infected hepatocytes and can be targets for T cells, even though intact CS protein has not been detected on the surface of the infected hepatocyte. A vaccine that induced CTL to parasite antigens might protect humans against malaria by eliminating liver stage parasites.
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1 March 1990
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March 01 1990
Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.
W R Weiss,
W R Weiss
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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S Mellouk,
S Mellouk
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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R A Houghten,
R A Houghten
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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M Sedegah,
M Sedegah
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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S Kumar,
S Kumar
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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M F Good,
M F Good
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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J A Berzofsky,
J A Berzofsky
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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L H Miller,
L H Miller
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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S L Hoffman
S L Hoffman
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
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W R Weiss
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
S Mellouk
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
R A Houghten
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
M Sedegah
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
S Kumar
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
M F Good
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
J A Berzofsky
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
L H Miller
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
S L Hoffman
Infectious Disease Department, Naval Medical Research Institute, Bethesda, Maryland 20814.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1990) 171 (3): 763–773.
Citation
W R Weiss, S Mellouk, R A Houghten, M Sedegah, S Kumar, M F Good, J A Berzofsky, L H Miller, S L Hoffman; Cytotoxic T cells recognize a peptide from the circumsporozoite protein on malaria-infected hepatocytes.. J Exp Med 1 March 1990; 171 (3): 763–773. doi: https://doi.org/10.1084/jem.171.3.763
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