DNA spanning a t(7;19) chromosomal translocation breakpoint was isolated from the human T cell line SUP-T7 established from an acute lymphoblastic leukemia. Nucleotide sequence analysis showed that the point of crossover on chromosome 7 occurred immediately adjacent to joining segment J beta 1.1 within the TCR-beta gene, suggesting that this translocation resulted from an error in TCR gene rearrangement. On chromosome 19, the translocation occurred within a previously uncharacterized transcriptional unit for which we propose the name lyl-1. An approximately 1.5-kb RNA is transcribed from this gene in a wide variety of hematolymphoid cell lines. The t(7;19) results in truncation of the lyl-1 gene and production of abnormal-sized RNAs, suggesting a role for lyl-1 in the pathogenesis of this leukemia.
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1 February 1988
Article|
February 01 1988
Chromosomal translocation involving the beta T cell receptor gene in acute leukemia.
M L Cleary,
M L Cleary
Department of Pathology, Stanford University School of Medicine, California 94305.
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J D Mellentin,
J D Mellentin
Department of Pathology, Stanford University School of Medicine, California 94305.
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J Spies,
J Spies
Department of Pathology, Stanford University School of Medicine, California 94305.
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S D Smith
S D Smith
Department of Pathology, Stanford University School of Medicine, California 94305.
Search for other works by this author on:
M L Cleary
Department of Pathology, Stanford University School of Medicine, California 94305.
J D Mellentin
Department of Pathology, Stanford University School of Medicine, California 94305.
J Spies
Department of Pathology, Stanford University School of Medicine, California 94305.
S D Smith
Department of Pathology, Stanford University School of Medicine, California 94305.
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1988) 167 (2): 682–687.
Citation
M L Cleary, J D Mellentin, J Spies, S D Smith; Chromosomal translocation involving the beta T cell receptor gene in acute leukemia.. J Exp Med 1 February 1988; 167 (2): 682–687. doi: https://doi.org/10.1084/jem.167.2.682
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