Recombinant human interleukin 5 is a selective activator of human eosinophil function.

Lopez, A F; Sanderson, C J; Gamble, J R; Campbell, H D; Young, I G; Vadas, M A

doi:10.1084/jem.167.1.219

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Article| January 01 1988

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

A F Lopez,

A F Lopez

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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C J Sanderson,

C J Sanderson

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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J R Gamble,

J R Gamble

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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H D Campbell,

H D Campbell

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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I G Young,

I G Young

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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M A Vadas

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

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Author and Article Information

A F Lopez

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

C J Sanderson

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

J R Gamble

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

H D Campbell

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

I G Young

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

M A Vadas

Division of Human Immunology, Institute of Medical and Veterinary Science, Adelaide, South Australia.

Online ISSN: 1540-9538

Print ISSN: 0022-1007

J Exp Med (1988) 167 (1): 219–224.

https://doi.org/10.1084/jem.167.1.219

Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.

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