The antibody response to the inulin [(In), beta-(2 leads to 1) fructosan] determinant of bacterial levan [(BL), a beta-(2 leads to 6) polyfructosan that contains beta-(2 leads to 1) branch points] requires the presence of the a haplotype of the Igh gene complex. BALB/c (Igh a) mice immunized with BL produce IgG anti-In antibodies of a single spectrotype by isoelectric focusing analysis. C57BL/6 mice, which possess the b haplotype of the Igh gene complex and which fail to produce anti-In antibodies, nevertheless possess a gene, spectrotype regulation gene 1 (Sr-1), that regulates the isoelectric focusing (IEF) pattern of anti-In antibodies in mice of the a haplotype. Thus, the IEF patterns of anti-In antibodies of (BALB/c x C57BL/6)F1 mice and of B.C8 mice (C57BL/Ka . Igh-Ca) are considerably more complex than those of BALB/c. Backcross analysis indicates that Sr-1 is not linked to the Igh complex, the major histocompatibility complex, or to the genes that code for coat color. Studies of the heterogeneity of anti-In antibodies in recombinant inbred lines and their progeny from matings to BALB/c and C.B20 (BALB/c . Igh-Cb) suggest the existence of other regulatory genes.
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1 May 1980
Article|
May 01 1980
Regulation of the anti-inulin antibody response by a nonallotype-linked gene.
K E Stein
C Bona
R Lieberman
C C Chien
W E Paul
Online ISSN: 1540-9538
Print ISSN: 0022-1007
J Exp Med (1980) 151 (5): 1088–1102.
Citation
K E Stein, C Bona, R Lieberman, C C Chien, W E Paul; Regulation of the anti-inulin antibody response by a nonallotype-linked gene.. J Exp Med 1 May 1980; 151 (5): 1088–1102. doi: https://doi.org/10.1084/jem.151.5.1088
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