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Volume 140, Issue 2
1 August 1974
Journal of Experimental Medicine Cover Image for Volume 140, Issue 2
Brief Definitive Report| August 01 1974

QUANTITATIVE STUDIES ON TUMOR ENHANCEMENT IN MICE : I. ENHANCEMENT OF SARCOMA I INDUCED BY IgM, IgG1, AND IgG2

Pablo Rubinstein,
Pablo Rubinstein
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
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Francine Decary,
Francine Decary
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
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Edwin W. Streun
Edwin W. Streun
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
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Author and Article Information
Pablo Rubinstein
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
Francine Decary
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
Edwin W. Streun
From the Laboratory of Serology and Genetics, The New York Blood Center, New York 10021, and the Department of Pathology, Mt. Sinai School of Medicine, City University of New York, New York 10029
Received: April 30 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 140 (2): 591–596.
https://doi.org/10.1084/jem.140.2.591
Article history
Received:
April 30 1974

The concentration of specific alloantibody in purified mouse immunoglobulin preparations was determined. When passively transferred in adequate doses, IgM, IgG1, and IgG2 antibodies all induced tumor enhancement in allogeneic hosts. IgM and IgG2 antibodies in high concentration led to inhibition of tumor growth. IgM and either IgG1 or IgG2 had additive effects on tumor enhancement. IgG1, but not IgG2, suppressed the inhibitory effect of IgM in high concentration.

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Copyright © 1974 by The Rockefeller University Press
1974
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