INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Ioachim , Harry L.; Keller , Steven E.; Dorsett , Brent H.; Pearse , Antonia

doi:10.1084/jem.139.6.1382

Article navigation

Article| June 01 1974

INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Harry L. Ioachim,

Harry L. Ioachim

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Search for other works by this author on:

This Site

PubMed

Google Scholar

Steven E. Keller,

Steven E. Keller

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Search for other works by this author on:

This Site

PubMed

Google Scholar

Brent H. Dorsett,

Brent H. Dorsett

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Search for other works by this author on:

This Site

PubMed

Google Scholar

Antonia Pearse

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author and Article Information

Harry L. Ioachim

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Steven E. Keller

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Brent H. Dorsett

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Antonia Pearse

From the Departments of Pathology of Lenox Hill Hospital and the College of Physicians and Surgeons of Columbia University, New York 10021

Received: January 21 1974

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1974

J Exp Med (1974) 139 (6): 1382–1394.

https://doi.org/10.1084/jem.139.6.1382

Gross virus-induced lymphoma cells express strong virus-associated (Gross murine leukemia virus [G-MuLV]) antigens and are consistently rejected when grafted in normal adult syngeneic rats. By contrast, similar grafts are tolerated and allowed to grow progressively by rats that have been injected at birth with deaggregated G-MuLV antigens. However, the tolerance induced by this procedure is only partial as the grafted lymphoma cells lose their G-MuLV membrane antigens. These cells showing an antigenic disjunction, with negative membrane and positive cytoplasmic G-MuLV antigenic expression, become transplantable in normal-nonconditioned adult recipients. By further grafting, the expression of cytoplasmic G-MuLV antigens is similarly lost while the lymphoma cells substantially increase their transplantability, rate of growth, and capacity for metastasis.

This content is only available as a PDF.

1974

You do not currently have access to this content.

Don't already have an account? Register

You could not be signed in. Please check your email address / username and password and try again.

INDUCTION OF PARTIAL IMMUNOLOGIC TOLERANCE IN RATS AND PROGRESSIVE LOSS OF CELLULAR ANTIGENICITY IN GROSS VIRUS LYMPHOMA

Sign in

Client Account

Sign in via your Institution

Suggested Content

Email alerts

This Feature Is Available To Subscribers Only