For transplantation of semiallogeneic bursal stem cells into cyclophosphamide-treated 3-day old chicks, two lines of chickens homozygous at the major histocompatibility locus and their F1 hybrids were used in reciprocal combinations. The semiallogeneic transplantations resulted in a complete restoration of antibody formation to sheep red blood cells (SRBC) and Brucella, of microscopic morphology of bursa fabricii, and of germinal center formation in the spleen. In contrast, allogeneic bursal stem cells were not effective in restoring secondary response to SRBC and germinal center formation, while they were able to reconstitute anti-Brucella responses and bursal morphology. These findings indicate an effective cooperation of donor and host cells leading to a complete restoration of the bursa-dependent lymphoid system, when the donor and recipient share at least one haplotype determining the major histocompatibility antigen complex.
Brief Definitive Report|
May 01 1974
COMPLETE RESTORATION OF BURSA-DEPENDENT IMMUNE SYSTEM AFTER TRANSPLANTATION OF SEMIALLOGENEIC STEM CELLS INTO IMMUNODEFICIENT CHICKS
Paavo Toivanen,
Paavo Toivanen
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
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Auli Toivanen,
Auli Toivanen
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
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Olli Vainio
Olli Vainio
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
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Paavo Toivanen
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
Auli Toivanen
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
Olli Vainio
From the Departments of Medical Microbiology and Medicine, Turku University, Turku, Finland
Received:
January 08 1974
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1974 by The Rockefeller University Press
1974
J Exp Med (1974) 139 (5): 1344–1349.
Article history
Received:
January 08 1974
Citation
Paavo Toivanen, Auli Toivanen, Olli Vainio; COMPLETE RESTORATION OF BURSA-DEPENDENT IMMUNE SYSTEM AFTER TRANSPLANTATION OF SEMIALLOGENEIC STEM CELLS INTO IMMUNODEFICIENT CHICKS . J Exp Med 1 May 1974; 139 (5): 1344–1349. doi: https://doi.org/10.1084/jem.139.5.1344
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