IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE

Garvin , A. J.; Spicer , S. S.; Parmley , R. T.; Munster , A. M.

doi:10.1084/jem.139.5.1077

Article navigation

Article| May 01 1974

IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE

A. J. Garvin,

A. J. Garvin

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

Search for other works by this author on:

This Site

PubMed

Google Scholar

S. S. Spicer,

S. S. Spicer

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

Search for other works by this author on:

This Site

PubMed

Google Scholar

R. T. Parmley,

R. T. Parmley

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

Search for other works by this author on:

This Site

PubMed

Google Scholar

A. M. Munster

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author and Article Information

A. J. Garvin

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

S. S. Spicer

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

R. T. Parmley

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

A. M. Munster

From the Departments of Pathology and Surgery, Medical University of South Carolina, Charleston, South Carolina 29401

Received: January 29 1974

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1974

J Exp Med (1974) 139 (5): 1077–1083.

https://doi.org/10.1084/jem.139.5.1077

Spleens and lymph nodes fixed lightly for optimal immunocytochemistry or processed routinely for surgical diagnosis disclosed strong selective immunostaining for IgG in numerous immunocytes in tumor-free areas. Areas involved by Hodgkin's disease revealed, in addition, strong immunostaining for IgG but not IgM in Reed-Sternberg cells and faint to strong staining in Hodgkin cells as well. Ultrastructurally the Reed-Sternberg and Hodgkin cells displayed abundant polyribosomes and sparse granular reticulum and appeared to form unexportable IgG on unbound ribosomes.

This content is only available as a PDF.

1974

You do not currently have access to this content.

Don't already have an account? Register

You could not be signed in. Please check your email address / username and password and try again.

IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE

Sign in

Client Account

Sign in via your Institution

Suggested Content

Email alerts

This Feature Is Available To Subscribers Only