The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is related to the major histocompatibility complex genotype on target lymphocytes. The strain combinations AQR-B10. T(6R) and B10.A(4R)-B10.A(2R) that result in significant mixed lymphocyte culture activation do not mediate cell-mediated lympholysis on sensitizing target lymphocytes; serologically defined regions (H-2K and H-2D) are identical within each combination. H-2K or H-2D region disparity alone does not cause cell-mediated lympholysis. However after mixed lymphocyte culture activation as seen with B10.A-B10.T(6R), a target cell bearing only an H-2K region difference from the effector cell is sensitive to cell-mediated lympholysis. Likewise an H-2D region difference is an adequate target after mixed lymphocyte culture activation of the effector cell in the combination B10.A(2R)-B10.D2.
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1 May 1973
Brief Definitive Report|
May 01 1973
CELL-MEDIATED LYMPHOLYSIS : IMPORTANCE OF SEROLOGICALLY DEFINED H-2 REGIONS
Barbara J. Alter,
Barbara J. Alter
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Dolores J. Schendel,
Dolores J. Schendel
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Marilyn L. Bach,
Marilyn L. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Fritz H. Bach,
Fritz H. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Jan Klein,
Jan Klein
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Jack H. Stimpfling
Jack H. Stimpfling
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
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Barbara J. Alter
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Dolores J. Schendel
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Marilyn L. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Fritz H. Bach
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Jan Klein
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Jack H. Stimpfling
From the Departments of Medical Genetics, Surgery, Pediatrics, and Pharmacology, University of Wisconsin, Madison, Wisconsin 53706; the Department of Human Genetics, School of Medicine, and the Department of Oral Biology, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48104; the McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401
Received:
February 06 1973
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1973 by The Rockefeller University Press
1973
J Exp Med (1973) 137 (5): 1303–1309.
Article history
Received:
February 06 1973
Citation
Barbara J. Alter, Dolores J. Schendel, Marilyn L. Bach, Fritz H. Bach, Jan Klein, Jack H. Stimpfling; CELL-MEDIATED LYMPHOLYSIS : IMPORTANCE OF SEROLOGICALLY DEFINED H-2 REGIONS . J Exp Med 1 May 1973; 137 (5): 1303–1309. doi: https://doi.org/10.1084/jem.137.5.1303
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