SH virus-associated antigens have been identified in the liver and blood by immunofluorescence. This antigenic expression of the hepatitis agent or its genome is found in the cytoplasm of hepatocytes and other cells of the liver. Acute hepatitis is associated with hepatocellular localization of SH antigen, whereas alternative or additional SH antigen in the cytoplasm of nonhepatocytes is observed in chronic or recurrent hepatitis. Persistent intrahepatic SH antigen has also been observed in conversion from acute to chronic hepatitis, and the persistence of this virus-associated antigen in the liver may serve a significant pathogenetic role in mediating direct anti-tissue responses as well as local immune complex reactions. Competitive inhibition studies of SH antigen suggest at least two antigenically and sterically independent determinants on the SH particle.
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1 October 1971
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October 01 1971
INTRAHEPATIC EXPRESSION OF SERUM HEPATITIS VIRUS-ASSOCIATED ANTIGENS
Thomas S. Edgington,
Thomas S. Edgington
From the Division of Clinical Pathology, Department of Experimental Pathology, Scripps Clinic and Research Foundation; and the Division of Gastroenterology, Department of Medicine, University of California-San Diego, La Jolla, California 92037
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Donald J. Ritt
Donald J. Ritt
From the Division of Clinical Pathology, Department of Experimental Pathology, Scripps Clinic and Research Foundation; and the Division of Gastroenterology, Department of Medicine, University of California-San Diego, La Jolla, California 92037
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Thomas S. Edgington
From the Division of Clinical Pathology, Department of Experimental Pathology, Scripps Clinic and Research Foundation; and the Division of Gastroenterology, Department of Medicine, University of California-San Diego, La Jolla, California 92037
Donald J. Ritt
From the Division of Clinical Pathology, Department of Experimental Pathology, Scripps Clinic and Research Foundation; and the Division of Gastroenterology, Department of Medicine, University of California-San Diego, La Jolla, California 92037
Received:
April 26 1971
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1971 by The Rockefeller University Press
1971
J Exp Med (1971) 134 (4): 871–885.
Article history
Received:
April 26 1971
Citation
Thomas S. Edgington, Donald J. Ritt; INTRAHEPATIC EXPRESSION OF SERUM HEPATITIS VIRUS-ASSOCIATED ANTIGENS . J Exp Med 1 October 1971; 134 (4): 871–885. doi: https://doi.org/10.1084/jem.134.4.871
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