THE MITOTIC POTENTIAL OF FIXED PHAGOCYTES IN THE LIVER AS REVEALED DURING THE DEVELOPMENT OF CELLULAR IMMUNITY

North , Robert J.

doi:10.1084/jem.130.2.315

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Article| August 01 1969

THE MITOTIC POTENTIAL OF FIXED PHAGOCYTES IN THE LIVER AS REVEALED DURING THE DEVELOPMENT OF CELLULAR IMMUNITY

Robert J. North

From the Trudeau Institute, Saranac Lake, New York 12983

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Author and Article Information

Robert J. North

From the Trudeau Institute, Saranac Lake, New York 12983

Received: April 09 1969

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1969

J Exp Med (1969) 130 (2): 315–326.

https://doi.org/10.1084/jem.130.2.315

Fixed macrophages in the liver of the mouse undergo mitosis in large numbers during an infection with Listeria monocytogenes. The macrophage mitotic response always precedes the expression of efficient host immunity to infection. It is suggested that macrophage proliferation is an important event in the development of host immunity to L. monocytogenes.

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