The preparation of large quantities of a stable, stroma-free hemoglobin solution without coagulant activity is described. Following infusion of this solution into phlebotomized dogs, there is no methemoglobin formation, no adverse effects on vital signs, and no demonstrable activation of blood coagulation. The hemoglobin maintains its oxygen-carrying capacity and liberates oxygen into tissues. Acute and chronic effects on renal function following infusion of this preparation were also studied and no effect on clearance of urea, creatinine, or P.A.H. could be demonstrated. There was no change in urinary output and histological sections revealed no lesions attributable to hemoglobin toxicity. It is concluded that a stroma-free hemoglobin solution may have use as a plasma expander.
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1 December 1967
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December 01 1967
EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER
S. Frederick Rabiner,
S. Frederick Rabiner
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
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J. Raymond Helbert,
J. Raymond Helbert
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
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Harry Lopas,
Harry Lopas
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
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Lila H. Friedman
Lila H. Friedman
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
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S. Frederick Rabiner
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
J. Raymond Helbert
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
Harry Lopas
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
Lila H. Friedman
From the Division of Clinical Hematology, Department of Medicine, Michael Reese Hospital and Medical Center, and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60616
Received:
July 17 1967
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1967 by The Rockefeller University Press
1967
J Exp Med (1967) 126 (6): 1127–1142.
Article history
Received:
July 17 1967
Citation
S. Frederick Rabiner, J. Raymond Helbert, Harry Lopas, Lila H. Friedman; EVALUATION OF A STROMA-FREE HEMOGLOBIN SOLUTION FOR USE AS A PLASMA EXPANDER . J Exp Med 1 December 1967; 126 (6): 1127–1142. doi: https://doi.org/10.1084/jem.126.6.1127
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