QUANTITATIVE ASPECTS OF THE RELEASE OF LEUKOCYTE PYROGEN FROM RABBIT BLOOD INCUBATED WITH ENDOTOXIN

Murphy , P. A.

doi:10.1084/jem.126.5.763

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Article| November 01 1967

QUANTITATIVE ASPECTS OF THE RELEASE OF LEUKOCYTE PYROGEN FROM RABBIT BLOOD INCUBATED WITH ENDOTOXIN

P. A. Murphy

From the Medical Research Council Body Temperature Research Unit, Department of the Regius Professor of Medicine, The Radcliffe Infirmary, Oxford, England

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Author and Article Information

P. A. Murphy

From the Medical Research Council Body Temperature Research Unit, Department of the Regius Professor of Medicine, The Radcliffe Infirmary, Oxford, England

Received: March 23 1967

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1967

J Exp Med (1967) 126 (5): 763–770.

https://doi.org/10.1084/jem.126.5.763

This paper describes the relations between the endotoxin concentration and leukocyte pyrogen yield when endotoxin is incubated with whole rabbit blood for 24 hr. The results provide strong evidence for the view that leukocyte pyrogen is not modified endotoxin, and also show that the simplified assay method described in the previous paper works reasonably well.

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QUANTITATIVE ASPECTS OF THE RELEASE OF LEUKOCYTE PYROGEN FROM RABBIT BLOOD INCUBATED WITH ENDOTOXIN

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