In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals.
Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response.
Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.
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Copyright © 1965 by The Rockefeller Institute
1965
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