The platelet injury produced by bacterial endotoxin and thrombin have been compared in studies utilizing citrated rabbit platelet-rich plasma. Endotoxin-induced platelet injury is characterized by a lag period, is progressive, and does not produce gross clot formation. Thrombin-induced platelet injury is immediate, non-progressive, and is associated with clot formation. The quantity of thrombin required to produce clot formation in this citrated system is less than that required to produce release of platelet 5-hydroxytryptamine. The endotoxin-induced platelet injury required extremely large quantities of heparin for inhibition. The platelet injury induced by thrombin can be inhibited by small quantities of heparin. It is concluded that the injurious effects of endotoxin on platelets is mediated through some mechanism other than thrombin formation.
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1 August 1964
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August 01 1964
EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN
Roger M. Des Prez
Roger M. Des Prez
From the Department of Medicine, The New York Hospital-Cornell Medical Center, New York
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Roger M. Des Prez
From the Department of Medicine, The New York Hospital-Cornell Medical Center, New York
Received:
March 30 1964
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1964 by The Rockefeller Institute
1964
J Exp Med (1964) 120 (2): 305–313.
Article history
Received:
March 30 1964
Citation
Roger M. Des Prez; EFFECTS OF BACTERIAL ENDOTOXIN ON RABBIT PLATELETS : III. COMPARISON OF PLATELET INJURY INDUCED BY THROMBIN AND BY ENDOTOXIN . J Exp Med 1 August 1964; 120 (2): 305–313. doi: https://doi.org/10.1084/jem.120.2.305
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