Further evidence of a cross-reactive relationship between a cell wall antigen of certain Group A streptococcal strains and mammalian heart tissue is provided by the demonstration that goat antisera to washed human or rabbit heart tissue homogenates exhibit precipitation with cell wall extract preparations. A single line of precipitation was observed in agar gel diffusion tests. Precipitating activity of goat antiheart sera was related to the γ-globulin fraction in zone electrophoresis. The cell wall antigen was demonstrated in cell wall extracts of a Type 5 and Type 19 but not of a Type 12 strain. Antigenic activity was concentrated in the same neutral salt and chromatographic fractions of acid extracts of cell wall previously reported to exhibit this activity by immunofluorescent inhibition of the cross-reaction of antistreptococcal serum with heart tissue.
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1 April 1964
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April 01 1964
IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI
Melvin H. Kaplan,
Melvin H. Kaplan
From the Department of Medicine, Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland
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Mary Louise Suchy
Mary Louise Suchy
From the Department of Medicine, Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland
Search for other works by this author on:
Melvin H. Kaplan
From the Department of Medicine, Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland
Mary Louise Suchy
From the Department of Medicine, Metropolitan General Hospital, and Western Reserve University School of Medicine, Cleveland
Received:
December 10 1963
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1964, by The Rockefeller Institute
1964
J Exp Med (1964) 119 (4): 643–650.
Article history
Received:
December 10 1963
Citation
Melvin H. Kaplan, Mary Louise Suchy; IMMUNOLOGIC RELATION OF STREPTOCOCCAL AND TISSUE ANTIGENS : II. CROSS-REACTION OF ANTISERA TO MAMMALIAN HEART TISSUE WITH A CELL WALL CONSTITUENT OF CERTAIN STRAINS OF GROUP A STREPTOCOCCI . J Exp Med 1 April 1964; 119 (4): 643–650. doi: https://doi.org/10.1084/jem.119.4.643
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