Two groups of adult rats fed a choline-deficient diet supplemented with neomycin in their drinking water for 250 or 350 days were protected against the development of liver fibrosis and cirrhosis. At the termination of the study these animals weighed more than others not receiving neomycin. This difference in weight did not appear to be caused by a growth-promoting effect of neomycin but rather reflected the increased severity of liver disease and a resultant weight loss in animals not receiving neomycin. Protection by neomycin was cancelled when Salmonella typhosa endotoxin was added to the drinking water. It was concluded that the protective effect of neomycin was mediated by an alteration in the intestinal microflora resulting in a reduction in the numbers of organisms contributing to intraluminal endotoxin. In the presence of choline deficiency, absorption of intraluminal endotoxin may contribute to the development of fibrosis and cirrhosis.
Skip Nav Destination
Article navigation
1 April 1964
Article|
April 01 1964
INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT
Selwyn A. Broitman,
Selwyn A. Broitman
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Search for other works by this author on:
Leonard S. Gottlieb,
Leonard S. Gottlieb
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Search for other works by this author on:
Norman Zamcheck
Norman Zamcheck
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Search for other works by this author on:
Selwyn A. Broitman
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Leonard S. Gottlieb
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Norman Zamcheck
From the Gastroenterology Laboratory, Mallory Institute of Pathology; Second and Fourth Medical (Harvard) Services, Boston City Hospital; Department of Medicine, Harvard Medical School; and the Departments of Pathology, Boston University, Tufts University, and Harvard Medical Schools
Received:
December 22 1963
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1964, by The Rockefeller Institute
1964
J Exp Med (1964) 119 (4): 633–642.
Article history
Received:
December 22 1963
Citation
Selwyn A. Broitman, Leonard S. Gottlieb, Norman Zamcheck; INFLUENCE OF NEOMYCIN AND INGESTED ENDOTOXIN IN THE PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN THE ADULT RAT . J Exp Med 1 April 1964; 119 (4): 633–642. doi: https://doi.org/10.1084/jem.119.4.633
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionSuggested Content
Email alerts
Advertisement