STUDIES ON HUMAN ANTIBODIES II. DISTRIBUTION OF GENETIC FACTORS

Allen , James C.; Kunkel , Henry G.; Kabat , Elvin A.

doi:10.1084/jem.119.3.453

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Article| March 01 1964

STUDIES ON HUMAN ANTIBODIES : II. DISTRIBUTION OF GENETIC FACTORS

James C. Allen,

James C. Allen

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

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Henry G. Kunkel,

Henry G. Kunkel

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

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Elvin A. Kabat

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

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Author and Article Information

James C. Allen

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

Henry G. Kunkel

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

Elvin A. Kabat

From The Rockefeller Institute, the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York

Received: November 28 1963

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1964

J Exp Med (1964) 119 (3): 453–465.

https://doi.org/10.1084/jem.119.3.453

Human antibodies against dextran, teichoic acid, blood group A substance, levan, tetanus toxoid, and nuclei were isolated and analyzed for their content of Gm(a), Gm(b), and Inv(a) γ-globulin genetic factors. The majority of these antibodies contained all the genetic factors determined in the donor's whole γ-globulin, but in many antibodies at very different concentrations. In a few instances specific factors could not be detected despite their presence in the individual's whole γ-globulin. Different antibodies isolated from the serum of the same individual showed different relative concentrations of genetic factors. The distribution of genetic factors seen in certain isolated human antibodies appeared to approach the selective occurrence of these factors in myeloma proteins.

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