ASSOCIATION OF NATURAL ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ1-MACROGLOBULINS

Michael , J. Gabriel; Rosen , Fred S.

doi:10.1084/jem.118.4.619

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Article| October 01 1963

ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ₁-MACROGLOBULINS

J. Gabriel Michael,

J. Gabriel Michael

From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston

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Fred S. Rosen

From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston

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Author and Article Information

J. Gabriel Michael

From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston

Fred S. Rosen

From the House of the Good Samaritan and the Department of Medicine, Children's Hospital Medical Center, and the Department of Pediatrics, Harvard Medical Center, Boston

Received: June 03 1963

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1963

J Exp Med (1963) 118 (4): 619–626.

https://doi.org/10.1084/jem.118.4.619

"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the γ₁-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of γ₂-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.

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ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE γ₁-MACROGLOBULINS