The intravenous injection of endotoxin in human plasma into rabbits produces a marked potentiation of lethal effect, when compared to the mortality associated with comparable doses of endotoxin in saline alone. A similar enhancement was noted with other heterologous plasma (guinea pig, rat) but not with homologous plasma. The potentiating factor is not in the albumin or gamma globulin fractions, is not concerned with fibrinogen, and is heat-labile. Tolerance of the recipient animal to endotoxin destroys the lethal effect. Within a period of 3 hours, endotoxin and human plasma may be administered separately, without regard to timing or sequence, without loss of the lethal effect. The enhancement of lethal effect is not avoided by pretreatment with heparin or cortisone. Preliminary experiments indicate that the loss of lethal effect found after incubation of endotoxin-plasma mixtures may be due to a separate inhibitor, but is not due to loss of the potentiating factor.
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1 August 1963
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August 01 1963
POTENTIATION OF THE LETHAL EFFECT OF ENDOTOXIN BY HETEROLOGOUS PLASMA
Fritz K. Beller,
Fritz K. Beller
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
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Charles H. Debrovner,
Charles H. Debrovner
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
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Gordon Watkins Douglas
Gordon Watkins Douglas
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
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Fritz K. Beller
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
Charles H. Debrovner
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
Gordon Watkins Douglas
From the Department of Obstetrics and Gynecology, New York University School of Medicine, New York
Received:
April 11 1963
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright © 1963, by The Rockefeller Institute
1963
J Exp Med (1963) 118 (2): 245–256.
Article history
Received:
April 11 1963
Citation
Fritz K. Beller, Charles H. Debrovner, Gordon Watkins Douglas; POTENTIATION OF THE LETHAL EFFECT OF ENDOTOXIN BY HETEROLOGOUS PLASMA . J Exp Med 1 August 1963; 118 (2): 245–256. doi: https://doi.org/10.1084/jem.118.2.245
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