PROPERTIES OF GUINEA PIG 7S ANTIBODIES II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS

Ovary , Zoltan; Benacerraf , Baruj; Bloch , Kurt J.

doi:10.1084/jem.117.6.951

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Article| June 01 1963

PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS

Zoltan Ovary,

Zoltan Ovary

From the Department of Pathology, New York University School of Medicine, New York

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Baruj Benacerraf,

Baruj Benacerraf

From the Department of Pathology, New York University School of Medicine, New York

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Kurt J. Bloch

From the Department of Pathology, New York University School of Medicine, New York

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Author and Article Information

Zoltan Ovary

From the Department of Pathology, New York University School of Medicine, New York

Baruj Benacerraf

From the Department of Pathology, New York University School of Medicine, New York

Kurt J. Bloch

From the Department of Pathology, New York University School of Medicine, New York

Received: January 24 1963

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1963

J Exp Med (1963) 117 (6): 951–964.

https://doi.org/10.1084/jem.117.6.951

Guinea pig 7Sγ₁ antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sγ₂ antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sγ₂ antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.

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PROPERTIES OF GUINEA PIG 7S ANTIBODIES : II. IDENTIFICATION OF ANTIBODIES INVOLVED IN PASSIVE CUTANEOUS AND SYSTEMIC ANAPHYLAXIS

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