REDUCTION OF SERUM COMPLEMENT IN RABBITS AFTER INJECTION OF ENDOTOXIN

Gilbert , Verne E.; Braude , Abraham I.

doi:10.1084/jem.116.4.477

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Article| October 01 1962

REDUCTION OF SERUM COMPLEMENT IN RABBITS AFTER INJECTION OF ENDOTOXIN

Verne E. Gilbert,

Verne E. Gilbert

From the Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh

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Abraham I. Braude

From the Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh

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Author and Article Information

Verne E. Gilbert

From the Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh

Abraham I. Braude

From the Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh

Received: June 06 1962

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1962

J Exp Med (1962) 116 (4): 477–490.

https://doi.org/10.1084/jem.116.4.477

Injection into rabbits of a consistently lethal dose of endotoxin regularly produced a rapid and sustained fall of complement levels and lowered the titers of antibody to endotoxin. Doses of endotoxin below the LD₅₀ lowered complement levels sporadically but not the titers of antibody to endotoxin. The possibility is discussed that complement may be involved in the mechanisms responsible for the lethal action of endotoxin.

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