ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS II. SUPPRESSIVE EFFECT OF THYMECTOMY AT BIRTH ON REACTIONS OF DELAYED (CELLULAR) HYPERSENSITIVITY AND THE CIRCULATING SMALL LYMPHOCYTE

Arnason , Barry G.; Janković , Branislav D.; Waksman , Byron H.; Wennersten , Christine

doi:10.1084/jem.116.2.177

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Article| August 01 1962

ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS : II. SUPPRESSIVE EFFECT OF THYMECTOMY AT BIRTH ON REACTIONS OF DELAYED (CELLULAR) HYPERSENSITIVITY AND THE CIRCULATING SMALL LYMPHOCYTE

Barry G. Arnason,

Barry G. Arnason

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Branislav D. Janković,

Branislav D. Janković

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Byron H. Waksman,

Byron H. Waksman

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Christine Wennersten

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

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Author and Article Information

Barry G. Arnason

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Branislav D. Janković

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Byron H. Waksman

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Christine Wennersten

From the Neurology Research Laboratory, Massachusetts General Hospital, and the Department of Bacteriology and Immunology, Harvard Medical School, Boston

Received: April 10 1962

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1962, by The Rockefeller Institute

1962

J Exp Med (1962) 116 (2): 177–186.

https://doi.org/10.1084/jem.116.2.177

In rats thymectomized at birth and tested in adult life, ability to develop autoallergic encephalomyelitis was completely suppressed, there was a marked diminution in the degree of tuberculin sensitization appearing after a single injection of mycobacteria in oil, rejection of skin homografts was markedly delayed, and adjuvant arthritis was not appreciably affected. At the same time there was a striking decrease in the circulating level of small lymphocytes.

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Copyright, 1962, by The Rockefeller Institute

1962

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ROLE OF THE THYMUS IN IMMUNE REACTIONS IN RATS : II. SUPPRESSIVE EFFECT OF THYMECTOMY AT BIRTH ON REACTIONS OF DELAYED (CELLULAR) HYPERSENSITIVITY AND THE CIRCULATING SMALL LYMPHOCYTE

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