INHIBITION OF CYTOCHROME OXIDASE BY AMINOACETONITRILE

Clemmons , J. J.; Jackson , E. B.

doi:10.1084/jem.115.3.555

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Article| March 01 1962

INHIBITION OF CYTOCHROME OXIDASE BY AMINOACETONITRILE

J. J. Clemmons,

J. J. Clemmons

From the Institute of Pathology, Western Reserve University, Cleveland

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E. B. Jackson, Jr.

From the Institute of Pathology, Western Reserve University, Cleveland

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Author and Article Information

J. J. Clemmons

From the Institute of Pathology, Western Reserve University, Cleveland

E. B. Jackson, Jr.

From the Institute of Pathology, Western Reserve University, Cleveland

Received: November 02 1961

Online ISSN: 1540-9538

Print ISSN: 0022-1007

Copyright, 1962, by The Rockefeller Institute

1962

J Exp Med (1962) 115 (3): 555–562.

https://doi.org/10.1084/jem.115.3.555

Aminoacetonitrile (AAN) decomposes with the formation of a substance that is a potent inhibitor of cytochrome oxidase. The inhibitor is probably cyanide. Connective tissue contains cytochrome oxidase that varies in amount with the maturity of the tissue and is also inhibited by the product of AAN decomposition.

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Copyright, 1962, by The Rockefeller Institute

1962

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