An autoimmune nephrosis produced in rats by repeated injections of kidney extract with Freund's adjuvant has been transferred by means of lymph node cells to recipient animals rendered tolerant by neonatal injection with spleen cells from prospective donors. Transfer of the disease was manifested in the recipients by the development of proteinuria, hypoalbuminemia, hypercholesterolemia,and histological changes. The latter consisted of glomerular epithelial swelling, increase in basement membrane material and the presence of protein droplets in the glomerular and tubular epithelium. Appropriate control experiments were negative. Attempts to transfer with serum were unsuccessful. The transfer described is believed to provide evidence for an immunological mechanism for kidney and adjuvant induced nephrosis in the rat.
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1 February 1962
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February 01 1962
TRANSFER OF AN AUTOIMMUNE NEPHROSIS IN THE RAT BY MEANS OF LYMPH NODE CELLS
Evelyn V. Hess,
Evelyn V. Hess
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
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Charles T. Ashworth,
Charles T. Ashworth
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
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Morris Ziff
Morris Ziff
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
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Evelyn V. Hess
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
Charles T. Ashworth
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
Morris Ziff
From the Departments of Internal Medicine, Rheumatic Diseases Unit, and Pathology, The University of Texas Southwestern Medical School, Dallas
Received:
September 05 1961
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1962, by The Rockefeller Institute
1962
J Exp Med (1962) 115 (2): 421–438.
Article history
Received:
September 05 1961
Citation
Evelyn V. Hess, Charles T. Ashworth, Morris Ziff; TRANSFER OF AN AUTOIMMUNE NEPHROSIS IN THE RAT BY MEANS OF LYMPH NODE CELLS . J Exp Med 1 February 1962; 115 (2): 421–438. doi: https://doi.org/10.1084/jem.115.2.421
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