Intradermal injection of a simple hapten (e.g., 1-fluoro-2,4-dinitrobenzene) in water-in-oil emulsion results in contact hypersensitivity to surface application of the homologous hapten and, after appearance of circulating antibody, in Arthus type hypersensitivity to a conjugate of homologous hapten with guinea pig serum. Intradermal administration of this conjugate induces delayed and subsequently Arthus hypersensitivity to the conjugate, but no evidence of a contact reaction to the hapten alone. When a conjugate of hapten plus solubilized guinea pig skin is used as the sensitizing antigen, both contact hypersensitivity to the hapten and delayed and/or Arthus reactions to the conjugate develop. These observations are consistent with the hypothesis that the specificity of contact sensitivity is directed toward some particular protein of the skin which has been modified by combination with hapten.
Article|
August 01 1961
THE SPECIFICITY OF ALLERGIC REACTIONS : III. CONTACT HYPERSENSITIVITY
S. B. Salvin,
S. B. Salvin
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana
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R. F. Smith
R. F. Smith
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana
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S. B. Salvin
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana
R. F. Smith
From the United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana
Received:
April 02 1961
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1961, by The Rockefeller Institute
1961
J Exp Med (1961) 114 (2): 185–194.
Article history
Received:
April 02 1961
Citation
S. B. Salvin, R. F. Smith; THE SPECIFICITY OF ALLERGIC REACTIONS : III. CONTACT HYPERSENSITIVITY . J Exp Med 1 August 1961; 114 (2): 185–194. doi: https://doi.org/10.1084/jem.114.2.185
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