STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT I. DEMONSTRATION OF AGGLUTINATING ANTIBODIES AGAINST GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

Klein , Paul G.; Burkholder , Peter M.

doi:10.1084/jem.111.1.93

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Article| January 01 1960

STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT : I. DEMONSTRATION OF AGGLUTINATING ANTIBODIES AGAINST GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

Paul G. Klein,

Paul G. Klein

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

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Peter M. Burkholder

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

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Author and Article Information

Paul G. Klein

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

Peter M. Burkholder

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

Received: August 20 1959

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1960

J Exp Med (1960) 111 (1): 93–106.

https://doi.org/10.1084/jem.111.1.93

Evidence is presented to show that guinea pig complement fixed on sensitized sheep red cells acts as a specific agglutinogen. Agglutinating antibodies that react with cell-fixed complement can be produced by immunizing rabbits with a complex of stromata-amboceptor-complement or with guinea pig serum globulin. These agglutinins can be removed by precipitation with guinea pig serum. They are, therefore, distinct from immunoconglutinins.

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STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT : I. DEMONSTRATION OF AGGLUTINATING ANTIBODIES AGAINST GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

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