STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT II. ANALYSIS OF SPECIFIC AGGLUTININS AGAINST CERTAIN COMPONENTS OF GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

Klein , Paul G.; Burkholder , Peter M.

doi:10.1084/jem.111.1.107

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Article| January 01 1960

STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT : II. ANALYSIS OF SPECIFIC AGGLUTININS AGAINST CERTAIN COMPONENTS OF GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

Paul G. Klein,

Paul G. Klein

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

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Peter M. Burkholder

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

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Author and Article Information

Paul G. Klein

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

Peter M. Burkholder

From the Department of Pathology, The New York Hospital-Cornell Medical Center, New York

Received: August 20 1959

Online ISSN: 1540-9538

Print ISSN: 0022-1007

1960

J Exp Med (1960) 111 (1): 107–117.

https://doi.org/10.1084/jem.111.1.107

Sheep erythrocytes sensitized with amboceptor and persensitized thereafter with guinea pig complement are agglutinated by rabbit anti-guinea pig globulin and by immune sera obtained by injection of rabbits with fixed complement. In this agglutination neither C'1 nor C'2 takes part. Fixed C'4 acts as an agglutinogen. An additional agglutinogen, distinct from C'4, was found on persensitized cells. This additional agglutinogen appears to be distinct from hemolytically active C'3.

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STUDIES ON THE ANTIGENIC PROPERTIES OF COMPLEMENT : II. ANALYSIS OF SPECIFIC AGGLUTININS AGAINST CERTAIN COMPONENTS OF GUINEA PIG COMPLEMENT FIXED ON SENSITIZED SHEEP ERYTHROCYTES

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