Highly purified pathological macroglobulins, which had been characterized electrophoretically and in the ultracentrifuge, were studied by the Ouchterlony gel diffusion technique.

These macroglobulins were shown to be antigenically related to normal γ1-macroglobulin (19S) as well as the 7S γ-globulins.

The pathological macroglobulins differ among each other and they are antigenically deficient when compared with the normal macroglobulin.

There is no correlation between the macroglobulin's antigenic structure and its physico-chemical properties.

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Copyright, 1957, by The Rockefeller Institute for Medical Research New York
1957
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