The results of the present study provide a striking demonstration of antibody orientation produced by the dominant antigens of the strains of influenza virus encountered at childhood. The homologous and heterologous antibody response to monovalent vaccines containing swine, PR8, FM1, or Cuppett viruses show that the antibody-forming mechanisms of children born after 1943 are oriented to strains of influenza A-prime; of recruits to strains of influenza A; and of persons over 30 years of age to a strain of swine influenza. It was shown that antibody response to heterotypic viruses appears to provide a serologic index of the amount of experience each of the segments of the general population studied have had with antigenic variants of influenza virus. Finally it was demonstrated that the antibody response of humans to strains of influenza A or influenza A-prime is remarkably uniform for isolates of each antigenic type.
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1 July 1956
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July 01 1956
A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE
Fred M. Davenport,
Fred M. Davenport
From the Department of Epidemiology and Virus Laboratory School of Public Health, Ann Arbor
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Albert V. Hennessy
Albert V. Hennessy
From the Department of Epidemiology and Virus Laboratory School of Public Health, Ann Arbor
Search for other works by this author on:
Fred M. Davenport
From the Department of Epidemiology and Virus Laboratory School of Public Health, Ann Arbor
Albert V. Hennessy
From the Department of Epidemiology and Virus Laboratory School of Public Health, Ann Arbor
Received:
April 01 1956
Online ISSN: 1540-9538
Print ISSN: 0022-1007
Copyright, 1956, by The Rockefeller Institute for Medical Research New York
1956
J Exp Med (1956) 104 (1): 85–97.
Article history
Received:
April 01 1956
Citation
Fred M. Davenport, Albert V. Hennessy; A SEROLOGIC RECAPITULATION OF PAST EXPERIENCES WITH INFLUENZA A; ANTIBODY RESPONSE TO MONOVALENT VACCINE . J Exp Med 1 July 1956; 104 (1): 85–97. doi: https://doi.org/10.1084/jem.104.1.85
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