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Ira Mellman
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Journal Articles

Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage

In Special Collection:
JEM Immunology Collection 2024 , Immunology Update Winter 2024 , Innate Immune Signaling: From Host Defense to Disease Pathogenesis
Ann-Jay Tong, Rebecca Leylek, Anna-Maria Herzner, Diamanda Rigas, Sara Wichner, Craig Blanchette, Siri Tahtinen, Christopher C. Kemball, Ira Mellman, Benjamin Haley, Emily C. Freund, Lélia Delamarre
Journal: Journal of Experimental Medicine
J Exp Med (2023) 221 (2): e20230341.
https://doi.org/10.1084/jem.20230341
Published: 14 December 2023
View article titled, Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage
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Includes: Supplementary data
Journal Articles

Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation

In Special Collection:
Immune Cell Biology 2023
Ofer Guttman, Adrien Le Thomas, Scot Marsters, David A. Lawrence, Lauren Gutgesell, Iratxe Zuazo-Gaztelu, Jonathan M. Harnoss, Simone M. Haag, Aditya Murthy, Geraldine Strasser, Zora Modrusan, Thomas Wu, Ira Mellman, Avi Ashkenazi
Journal: Journal of Cell Biology
J Cell Biol (2022) 221 (6): e202111068.
https://doi.org/10.1083/jcb.202111068
Published: 21 April 2022
View article titled, Antigen-derived peptides engage the ER stress sensor IRE1α to curb dendritic cell cross-presentation
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Includes: Supplementary data
Journal Articles

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers

In Special Collection:
2022 Clinical Collection on Cancer
Allyson L. Byrd, Menghan Liu, Kei E. Fujimura, Svetlana Lyalina, Deepti R. Nagarkar, Bruno Charbit, Jacob Bergstedt, Etienne Patin, Oliver J. Harrison, Lluís Quintana-Murci, Ira Mellman, Darragh Duffy, Matthew L. Albert, the Milieu Intérieur Consortium
Journal: Journal of Experimental Medicine
J Exp Med (2020) 218 (1): e20200606.
https://doi.org/10.1084/jem.20200606
Published: 11 November 2020
View article titled, Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers
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Includes: Supplementary data
Journal Articles

Mutation position is an important determinant for predicting cancer neoantigens

In Special Collection:
JEM 2020 Update on Cancer Immunology and Immunotherapy , JEM Cancer Collection 2020 , JEM Cancer Collection 2021
Aude-Hélène Capietto, Suchit Jhunjhunwala, Samuel B. Pollock, Patrick Lupardus, Jim Wong, Lena Hänsch, James Cevallos, Yajun Chestnut, Ajay Fernandez, Nicolas Lounsbury, Tamaki Nozawa, Manmeet Singh, Zhiyuan Fan, Cecile C. de la Cruz, Qui T. Phung, Lucia Taraborrelli, Benjamin Haley, Jennie R. Lill, Ira Mellman, Richard Bourgon, Lélia Delamarre
Journal: Journal of Experimental Medicine
J Exp Med (2020) 217 (4): e20190179.
https://doi.org/10.1084/jem.20190179
Published: 15 January 2020
View article titled, Mutation position is an important determinant for predicting cancer neoantigens
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Includes: Supplementary data
Journal Articles

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

In Special Collection:
Cancer Plasticity and Heterogeneity , Cell Biology of Cancer 2018
Manuel Viotti, Catherine Wilson, Mark McCleland, Hartmut Koeppen, Benjamin Haley, Suchit Jhunjhunwala, Christiaan Klijn, Zora Modrusan, David Arnott, Marie Classon, Jean-Philippe Stephan, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2017) 217 (2): 763–777.
https://doi.org/10.1083/jcb.201705031
Published: 11 December 2017
View article titled, SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer
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Includes: Supplementary data
Journal Articles

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation

In Special Collection:
Mitochondria and Autophagy 2018 , Cell Biology of Infection and the Immune Response 2018
Bryan Vander Lugt, Jeremy Riddell, Aly A. Khan, Jason A. Hackney, Justin Lesch, Jason DeVoss, Matthew T. Weirauch, Harinder Singh, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2017) 216 (3): 779–792.
https://doi.org/10.1083/jcb.201512012
Published: 27 January 2017
View article titled, Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation
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Includes: Supplementary data
Journal Articles

Natural killer cell granules converge to avoid collateral damage

Alex T. Ritter, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2016) 215 (6): 765–767.
https://doi.org/10.1083/jcb.201612003
Published: 08 December 2016
View article titled, Natural killer cell granules converge to avoid collateral damage
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Journal Articles

A Nobel Prize for membrane traffic: Vesicles find their journey’s end

Ira Mellman, Scott D. Emr
Journal: Journal of Cell Biology
J Cell Biol (2013) 203 (4): 559–561.
https://doi.org/10.1083/jcb.201310134
Published: 08 November 2013
View article titled, A Nobel Prize for membrane traffic: Vesicles find their journey’s end
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Journal Articles

MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

Jaehak Oh, Nan Wu, Günther Baravalle, Benjamin Cohn, Jessica Ma, Bryan Lo, Ira Mellman, Satoshi Ishido, Mark Anderson, Jeoung-Sook Shin
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (6): 1069–1077.
https://doi.org/10.1084/jem.20122695
Published: 27 May 2013
View article titled, MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
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Includes: Supplementary data
Journal Articles

Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation

Lillian Cohn, Bithi Chatterjee, Filipp Esselborn, Anna Smed-Sörensen, Norihiro Nakamura, Cécile Chalouni, Byoung-Chul Lee, Richard Vandlen, Tibor Keler, Peter Lauer, Dirk Brockstedt, Ira Mellman, Lélia Delamarre
Journal: Journal of Experimental Medicine
J Exp Med (2013) 210 (5): 1049–1063.
https://doi.org/10.1084/jem.20121251
Published: 08 April 2013
View article titled, Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation
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Journal Articles

Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways

Bryan Lo, Geraldine Strasser, Meredith Sagolla, Cary D. Austin, Melissa Junttila, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2012) 199 (7): 1117–1130.
https://doi.org/10.1083/jcb.201208080
Published: 24 December 2012
View article titled, Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
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Includes: Supplementary data
Journal Articles

Remembering Ralph Steinman

Jacques Banchereau, Fern Cohn, Kayo Inaba, Bill Muller, Ira Mellman, Carl Nathan, Michel Nussenzweig, Anne O’Garra, Bob Seder, Gerold Schuler, Alan Sher
Journal: Journal of Experimental Medicine
J Exp Med (2011) 208 (12): 2343–2347.
https://doi.org/10.1084/jem.20112295
Published: 21 November 2011
View article titled, Remembering Ralph Steinman
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Journal Articles

A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells

Stephen S. Francis, Jeff Sfakianos, Bryan Lo, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2011) 193 (1): 219–233.
https://doi.org/10.1083/jcb.201009001
Published: 28 March 2011
View article titled, A hierarchy of signals regulates entry of membrane proteins into the ciliary membrane domain in epithelial cells
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Journal Articles

Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells

Glen A. Farr, Michael Hull, Ira Mellman, Michael J. Caplan
Journal: Journal of Cell Biology
J Cell Biol (2009) 186 (2): 269–282.
https://doi.org/10.1083/jcb.200901021
Published: 20 July 2009
View article titled, Membrane proteins follow multiple pathways to the basolateral cell surface in polarized epithelial cells
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Includes: Supplementary data
Journal Articles

Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii–infected dendritic cells

Romina S. Goldszmid, Isabelle Coppens, Avital Lev, Pat Caspar, Ira Mellman, Alan Sher
Journal: Journal of Experimental Medicine
J Exp Med (2009) 206 (2): 399–410.
https://doi.org/10.1084/jem.20082108
Published: 19 January 2009
View article titled, Host ER–parasitophorous vacuole interaction provides a route of entry for antigen cross-presentation in Toxoplasma gondii–infected dendritic cells
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Includes: Supplementary data
Journal Articles

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

Yuntao S. Mao, Masaki Yamaga, Xiaohui Zhu, Yongjie Wei, Hui-Qiao Sun, Jing Wang, Mia Yun, Yanfeng Wang, Gilbert Di Paolo, Michael Bennett, Ira Mellman, Charles S. Abrams, Pietro De Camilli, Christopher Y. Lu, Helen L. Yin
Journal: Journal of Cell Biology
J Cell Biol (2009) 184 (2): 281–296.
https://doi.org/10.1083/jcb.200806121
Published: 19 January 2009
View article titled, Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis
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Includes: Supplementary data
Journal Articles

By the scientists, for the scientists

Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2009) 184 (1): 7–9.
https://doi.org/10.1083/jcb.200812145
Published: 12 January 2009
View article titled, By the scientists, for the scientists
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Journal Articles

George E. Palade, Cell Biology and The JCB

Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2008) 183 (3): 365.
https://doi.org/10.1083/jcb.200810087
Published: 20 October 2008
View article titled, George E. Palade, Cell Biology and The JCB
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Includes: Supplementary data
Journal Articles

Spinophilin participates in information transfer at immunological synapses

Ona Bloom, Julia J. Unternaehrer, Aimin Jiang, Jeong-Sook Shin, Lélia Delamarre, Patrick Allen, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2008) 181 (2): 203–211.
https://doi.org/10.1083/jcb.200711149
Published: 14 April 2008
View article titled, Spinophilin participates in information transfer at immunological synapses
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Includes: Supplementary data
Journal Articles

Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells

Jeff Sfakianos, Akashi Togawa, Sandra Maday, Mike Hull, Marc Pypaert, Lloyd Cantley, Derek Toomre, Ira Mellman
Journal: Journal of Cell Biology
J Cell Biol (2007) 179 (6): 1133–1140.
https://doi.org/10.1083/jcb.200709111
Published: 10 December 2007
View article titled, Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells
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Includes: Supplementary data