Figure 1. Longitudinal treatment response, marrow findings, cytokine profile, and functional confirmation of TLR8 p.Phe494Tyr as a gain-of-function variant. (a) Patient ANC and different therapies over time. Dashed line represents level of 500 More about this image found in Longitudinal treatment response, marrow findings, cytokine profile, and fun...

Figure 1. Timeline of P1 disease course: infectious complications and successive immunosupressive and anti-infectious treatments are shown. (A) Timeline of P1 disease course highlighting infectious complications and successive immunosuppressive More about this image found in Timeline of P1 disease course: infectious complications and successive immu...

Figure 1. NADPH oxidase assembly and the functional DHR assay. (A) Schematic representation of the phagocyte NADPH oxidase complex in the resting (left) and activated (right) states. P, phosphorylation. (B) Schematic representation of DHR More about this image found in NADPH oxidase assembly and the functional DHR assay. (A) Schematic represe...

Figure 2. Signaling pathways regulating the expression and activation of NADPH oxidase subunits. Proteins in which genetic defects have been shown to affect NADPH oxidase expression/activation in humans are highlighted in red. NADPH oxidase core More about this image found in Signaling pathways regulating the expression and activation of NADPH oxidas...

Figure S1. Some examples of the clinical skin lesions found in patients in this study are provided. (A and B) Examples of clinical skin lesions (case 16) (A: right arm, B: left arm). Initial presentation of erythematous, urticated papules and More about this image found in Some examples of the clinical skin lesions found in patients in this study ...

Figure 1. Summary of skin biopsy histopathologic features in AOSD. Bar graph showing skin biopsy histopathologic features in Adult-Onset Stills Disease. The horizontal axis represents the number of occurrences, ranging from 0 to 16. The More about this image found in Summary of skin biopsy histopathologic features in AOSD. Bar graph show...

Figure 2. Histological features of skin biopsy in patients with Still's disease. (A–D) Spectrum of histopathological changes in skin biopsy specimens of patients with AOSD (hematoxylin and eosin stain). (A–D) Panels represent four unique More about this image found in Histological features of skin biopsy in patients with Still's disease. (A–D...

Figure 1. IFN-α2 neutralization assays on serum from hepatitis patients and healthy controls. (A) Age and sex distributions of hepatitis C patients treated with IFN-α (n = 1,115). The blue bar corresponds to male patients, and the pink bar More about this image found in IFN-α2 neutralization assays on serum from hepatitis patients and healthy c...

Figure 2. Neutralization assays against IFN-ω and IFN-β in the selected subcohort. (A) Neutralization assay against IFN-ω in a randomly selected subcohort representative of the overall cohort with respect to age, sex, and the prevalence of More about this image found in Neutralization assays against IFN-ω and IFN-β in the selected subcohort. (A...

Figure 3. AAN-I-IFN detection and clinical characteristics of the patients. (A) AAN-IFN-α2 (100 pg/ml) positivity rates, by age and sex, in the IFN-α treatment (+) group. In men, autoantibodies were detected in 1.7% of individuals aged under 49 More about this image found in AAN-I-IFN detection and clinical characteristics of the patients. (A) AAN-...

Figure 4. Temporal changes in AAN-IFN-α2 neutralizing activity and serum IFN-α2 concentrations in patients with hepatitis C. (A) Temporal dynamics of AAN-IFN-α2 (100 pg/ml) detection in 15 cases from the IFN-α treatment (+) group with More about this image found in Temporal changes in AAN-IFN-α2 neutralizing activity and serum IFN-α2 conce...

Figure 1. Geographic distribution, allele frequency, and clinical features of IRAK4 deficiency. (A) Geographic distribution of reported families with IRAK4 deficiency in East Asia. Families were identified from previously published reports ( More about this image found in Geographic distribution, allele frequency, and clinical features of IRAK4 d...

Daniel L. Kastner. Courtesy of Sudhir Gupta. A headshot of Daniel L. Kastner. More about this image found in Daniel L. Kastner. Courtesy of Sudhir Gupta. A headshot of Daniel L. Kas...