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Voltage-Gated Na Channels
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Journal Articles

Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction

Noortje W.M. van den Braak, Samuel Kuehs, Greta Z. Peschke, Barbara Namer, Annette Lischka, Katja Eggermann, Christina Dumke, Vishal Sudha Bhagavath Eswaran, Stefan Nikolin, Joachim Weis, Jörg B. Schulz, Angelika Lampert, Ingo Kurth, Roman Rolke, Enrico Leipold, Maike F. Dohrn
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413691.
https://doi.org/10.1085/jgp.202413691
Published: 24 October 2025
View article titled, Altered NaV1.9 channel activity in two Tyr66Ser variant carriers with small fiber dysfunction
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Includes: Supplementary data
Journal Articles

Voltage-gated sodium channels: Mechanisms, disease, and a growing research community

Hugues Abriel, Angelika Lampert
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202513878.
https://doi.org/10.1085/jgp.202513878
Published: 10 October 2025
View article titled, Voltage-gated sodium channels: Mechanisms, disease, and a growing research community
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Journal Articles

Investigating the role of the I–II linker in Nav1.5 channel function

Emily Wagner, Martina Marras, Shashi Kumar, Jacob Kelley, Kiersten Ruff, Jonathan Silva
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (6): e202413692.
https://doi.org/10.1085/jgp.202413692
Published: 04 September 2025
View article titled, Investigating the role of the I–II linker in Nav1.5 channel function
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Includes: Supplementary data
Journal Articles

Mind the midpoints: Rethinking variability in cardiac INa

Colleen E. Clancy
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (5): e202413633.
https://doi.org/10.1085/jgp.202413633
Published: 16 July 2025
View article titled, Mind the midpoints: Rethinking variability in cardiac INa
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Journal Articles

Variability in reported midpoints of (in)activation of cardiac INa

Michael Clerx, Paul G.A. Volders, Gary R. Mirams
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (5): e202413621.
https://doi.org/10.1085/jgp.202413621
Published: 16 July 2025
View article titled, Variability in reported midpoints of (in)activation of cardiac INa
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Includes: Supplementary data
Journal Articles

Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism

In Special Collection:
JGP Highlights Collection 2025
Peter Hull, Angelika Lampert
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413683.
https://doi.org/10.1085/jgp.202413683
Published: 03 June 2025
View article titled, Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism
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Journal Articles

Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413597.
https://doi.org/10.1085/jgp.202413597
Published: 05 May 2025
View article titled, Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons
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Includes: Supplementary data
Journal Articles

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)

In Special Collection:
Neuroscience Collection 2025
John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202513778.
https://doi.org/10.1085/jgp.202513778
Published: 28 April 2025
View article titled, Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
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Journal Articles

Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826

In Special Collection:
Neuroscience Collection 2025
Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert G. Stewart, Patric M. Vaelli, Bruce P. Bean
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413719.
https://doi.org/10.1085/jgp.202413719
Published: 26 March 2025
View article titled, Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826
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Journal Articles

Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders

Christian Jorgensen
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413744.
https://doi.org/10.1085/jgp.202413744
Published: 23 January 2025
View article titled, Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders
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Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View article titled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View article titled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

How could simulations elucidate Nav1.5 channel blockers mechanism?

Tanadet Pipatpolkai
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413730.
https://doi.org/10.1085/jgp.202413730
Published: 07 January 2025
View article titled, How could simulations elucidate Nav1.5 channel blockers mechanism?
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

In Special Collection:
JGP Highlights Collection 2025
Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View article titled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
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Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

In Special Collection:
JGP Highlights Collection 2025
Yichen Liu, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413667.
https://doi.org/10.1085/jgp.202413667
Published: 27 November 2024
View article titled, A sodium channel mutant removes fast inactivation with the inactivation particle bound
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Includes: Supplementary data
Journal Articles

Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

In Special Collection:
Neuroscience Collection 2025
Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (11): e202413596.
https://doi.org/10.1085/jgp.202413596
Published: 08 October 2024
View article titled, Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
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Includes: Supplementary data
Journal Articles

ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents

Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (10): e202413563.
https://doi.org/10.1085/jgp.202413563
Published: 23 July 2024
View article titled, ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents
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Includes: Supplementary data