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Journal Articles

Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons

Joseph L. Ransdell, Yarimar Carrasquillo, Marie K. Bosch, Rebecca L. Mellor, David M. Ornitz, Jeanne M. Nerbonne
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413597.
https://doi.org/10.1085/jgp.202413597
Published: 05 May 2025
View articletitled, Loss of intracellular FGF14 (iFGF14) increases excitability of mature hippocampal pyramidal neurons
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Includes: Supplementary data
Journal Articles

Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)

John N. Wood, Nieng Yan, Jian Huang, Jing Zhao, Armen Akopian, James J. Cox, C. Geoffrey Woods, Mohammed A. Nassar
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202513778.
https://doi.org/10.1085/jgp.202513778
Published: 28 April 2025
View articletitled, Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine)
Open the PDF for Sensory neuron sodium channels as pain targets; from cocaine to Journavx (VX-548, suzetrigine) in another window
Journal Articles

Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826

Sooyeon Jo, Akie Fujita, Tomás Osorno, Robert G. Stewart, Patric M. Vaelli, Bruce P. Bean
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (4): e202413719.
https://doi.org/10.1085/jgp.202413719
Published: 26 March 2025
View articletitled, Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826
Open the PDF for Differential state-dependent Nav1.8 inhibition by suzetrigine, LTGO-33, and A-887826 in another window
Journal Articles

Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders

Christian Jorgensen
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413744.
https://doi.org/10.1085/jgp.202413744
Published: 23 January 2025
View articletitled, Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders
Open the PDF for Understanding the role of mutations in voltage-gated sodium ion channels for cardiovascular disorders in another window
Journal Articles

The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels

Eslam Elhanafy, Amin Akbari Ahangar, Rebecca Roth, Tamer M. Gamal El-Din, John R. Bankston, Jing Li
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413669.
https://doi.org/10.1085/jgp.202413669
Published: 17 January 2025
View articletitled, The differential impacts of equivalent gating-charge mutations in voltage-gated sodium channels
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Includes: Supplementary data
Journal Articles

Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore

Elaine Tao, Ben Corry
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413658.
https://doi.org/10.1085/jgp.202413658
Published: 07 January 2025
View articletitled, Drugs exhibit diverse binding modes and access routes in the Nav1.5 cardiac sodium channel pore
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Journal Articles

How could simulations elucidate Nav1.5 channel blockers mechanism?

Tanadet Pipatpolkai
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2025) 157 (2): e202413730.
https://doi.org/10.1085/jgp.202413730
Published: 07 January 2025
View articletitled, How could simulations elucidate Nav1.5 channel blockers mechanism?
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Journal Articles

Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites

Christopher A. Beaudoin, Manas Kohli, Samantha C. Salvage, Hengrui Liu, Samuel J. Arundel, Samir W. Hamaia, Ming Lei, Christopher L.-H. Huang, Antony P. Jackson
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413609.
https://doi.org/10.1085/jgp.202413609
Published: 16 December 2024
View articletitled, Isoform-specific N-linked glycosylation of NaV channel α-subunits alters β-subunit binding sites
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Journal Articles

A sodium channel mutant removes fast inactivation with the inactivation particle bound

Yichen Liu, Francisco Bezanilla
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 157 (1): e202413667.
https://doi.org/10.1085/jgp.202413667
Published: 27 November 2024
View articletitled, A sodium channel mutant removes fast inactivation with the inactivation particle bound
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Includes: Supplementary data
Journal Articles

Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

Dmytro V. Vasylyev, Peng Zhao, Betsy R. Schulman, Stephen G. Waxman
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (11): e202413596.
https://doi.org/10.1085/jgp.202413596
Published: 08 October 2024
View articletitled, Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain
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Includes: Supplementary data
Journal Articles

ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents

Rita de Cássia Collaço, Filip Van Petegem, Frank Bosmans
Journal: Journal of General Physiology
Series: Voltage-Gated Na Channels
J Gen Physiol (2024) 156 (10): e202413563.
https://doi.org/10.1085/jgp.202413563
Published: 23 July 2024
View articletitled, ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents
Open the PDF for ω-Grammotoxin-SIA inhibits voltage-gated Na+ channel currents in another window
Includes: Supplementary data