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Journal Articles

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

David Fedida, Daniel Sastre, Ying Dou, Maartje Westhoff, Jodene Eldstrom

J Gen Physiol (2024) 156 (3): e202313465.

https://doi.org/10.1085/jgp.202313465

Published: 31 January 2024

View article titled, Evaluating sequential and allosteric activation models in IKs channels with mutated voltage sensors

Journal Articles

Mechanism of external K⁺ sensitivity of KCNQ1 channels

Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan, Liana Mkrtchyan, Tatev Karapetyan, Ernest Sargsyan, Matthias Kneussel, Karen Nazaryan, Jürgen R. Schwarz, David Fedida, Vitya Vardanyan

J Gen Physiol (2023) 155 (5): e202213205.

https://doi.org/10.1085/jgp.202213205

Published: 21 February 2023

View article titled, Mechanism of external K+ sensitivity of KCNQ1 channels

Includes: Supplementary data

Journal Articles

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

Jodene Eldstrom, Donald A. McAfee, Ying Dou, Yundi Wang, David Fedida

J Gen Physiol (2021) 153 (12): e202112969.

https://doi.org/10.1085/jgp.202112969

Published: 12 October 2021

View article titled, ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

Journal Articles

cAMP-dependent regulation of I_Ks single-channel kinetics

In Special Collection:

Cardiovascular Physiology 2018

Emely Thompson, Jodene Eldstrom, Maartje Westhoff, Donald McAfee, Elise Balse, David Fedida

J Gen Physiol (2017) 149 (8): 781–798.

https://doi.org/10.1085/jgp.201611734

Published: 07 July 2017

View article titled, cAMP-dependent regulation of IKs single-channel kinetics

Includes: Supplementary data

Journal Articles

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

Zhuren Wang, Ying Dou, Samuel J. Goodchild, Zeineb Es-Salah-Lamoureux, David Fedida

J Gen Physiol (2013) 141 (4): 431–443.

https://doi.org/10.1085/jgp.201210942

Published: 11 March 2013

View article titled, Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

Includes: Supplementary data

Journal Articles

Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

Samuel J. Goodchild, Hongjian Xu, Zeineb Es-Salah-Lamoureux, Christopher A. Ahern, David Fedida

J Gen Physiol (2012) 140 (5): 495–511.

https://doi.org/10.1085/jgp.201210823

Published: 15 October 2012

View article titled, Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

Includes: Supplementary data

Journal Articles

Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence

Andrew James Horne, Christian Joseph Peters, Thomas William Claydon, David Fedida

J Gen Physiol (2010) 136 (1): 83–99.

https://doi.org/10.1085/jgp.201010413

Published: 28 June 2010

View article titled, Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence

Includes: Supplementary data

Journal Articles

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of I_Ks

Jodene Eldstrom, Hongjian Xu, Daniel Werry, Congbao Kang, Matthew E. Loewen, Amanda Degenhardt, Shubhayan Sanatani, Glen F. Tibbits, Charles Sanders, David Fedida

J Gen Physiol (2010) 135 (5): 433–448.

https://doi.org/10.1085/jgp.200910351

Published: 26 April 2010

View article titled, Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs

Includes: Supplementary data

Journal Articles

Control of voltage-gated K⁺ channel permeability to NMDG⁺ by a residue at the outer pore

Zhuren Wang, Nathan C. Wong, Yvonne Cheng, Steven J. Kehl, David Fedida

J Gen Physiol (2009) 133 (4): 361–374.

https://doi.org/10.1085/jgp.200810139

Published: 30 March 2009

View article titled, Control of voltage-gated K+ channel permeability to NMDG+ by a residue at the outer pore

Includes: Supplementary data

Journal Articles

Voltage Clamp Fluorimetry Reveals a Novel Outer Pore Instability in a Mammalian Voltage-gated Potassium Channel

Moninder Vaid, Thomas W. Claydon, Saman Rezazadeh, David Fedida

J Gen Physiol (2008) 132 (2): 209–222.

https://doi.org/10.1085/jgp.200809978

Published: 14 July 2008

View article titled, Voltage Clamp Fluorimetry Reveals a Novel Outer Pore Instability in a Mammalian Voltage-gated Potassium Channel

Journal Articles

A Direct Demonstration of Closed-State Inactivation of K⁺ Channels at Low pH

Thomas W. Claydon, Moni Vaid, Saman Rezazadeh, Daniel C.H. Kwan, Steven J. Kehl, David Fedida

J Gen Physiol (2007) 129 (5): 437–455.

https://doi.org/10.1085/jgp.200709774

Published: 30 April 2007

View article titled, A Direct Demonstration of Closed-State Inactivation of K+ Channels at Low pH

Journal Articles

NH₂-terminal Inactivation Peptide Binding to C-type–inactivated Kv Channels

Harley T. Kurata, Zhuren Wang, David Fedida

J Gen Physiol (2004) 123 (5): 505–520.

https://doi.org/10.1085/jgp.200308956

Published: 12 April 2004

View article titled, NH2-terminal Inactivation Peptide Binding to C-type–inactivated Kv Channels

Includes: Supplementary data

Journal Articles

Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K⁺ Current Inhibition

Shetuan Zhang, Harley T. Kurata, Steven J. Kehl, David Fedida

J Gen Physiol (2003) 121 (3): 215–225.

https://doi.org/10.1085/jgp.20028760

Published: 24 February 2003

View article titled, Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K+ Current Inhibition

Includes: Supplementary data

Journal Articles

Uncoupling of Gating Charge Movement and Closure of the Ion Pore During Recovery from Inactivation in the Kv1.5 Channel

Zhuren Wang, David Fedida

J Gen Physiol (2002) 120 (2): 249–260.

https://doi.org/10.1085/jgp.20028591

Published: 30 July 2002

View article titled, Uncoupling of Gating Charge Movement and Closure of the Ion Pore During Recovery from Inactivation in the Kv1.5 Channel

Journal Articles

Altered State Dependence of C-Type Inactivation in the Long and Short Forms of Human Kv1.5

Harley T. Kurata, Gordon S. Soon, David Fedida

J Gen Physiol (2001) 118 (3): 315–332.

https://doi.org/10.1085/jgp.118.3.315

Published: 27 August 2001

View article titled, Altered State Dependence of C-Type Inactivation in the Long and Short Forms of Human Kv1.5

Journal Articles

On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K⁺ Channel, hKv1.5

Fred S.P. Chen, David Fedida

J Gen Physiol (1998) 111 (4): 539–554.

https://doi.org/10.1085/jgp.111.4.539

Published: 01 April 1998

View article titled, On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K+ Channel, hKv1.5

Journal Articles

Allosteric Effects of Permeating Cations on Gating Currents during K⁺ Channel Deactivation

Fred S.P. Chen, David Steele, David Fedida

J Gen Physiol (1997) 110 (2): 87–100.

https://doi.org/10.1085/jgp.110.2.87

Published: 01 August 1997

View article titled, Allosteric Effects of Permeating Cations on Gating Currents during K+ Channel Deactivation

NARROW

Evaluating sequential and allosteric activation models in I_Ks channels with mutated voltage sensors

Mechanism of external K⁺ sensitivity of KCNQ1 channels

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

cAMP-dependent regulation of I_Ks single-channel kinetics

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels

Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations

Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of I_Ks

Control of voltage-gated K⁺ channel permeability to NMDG⁺ by a residue at the outer pore

Voltage Clamp Fluorimetry Reveals a Novel Outer Pore Instability in a Mammalian Voltage-gated Potassium Channel

A Direct Demonstration of Closed-State Inactivation of K⁺ Channels at Low pH

NH₂-terminal Inactivation Peptide Binding to C-type–inactivated Kv Channels

Rapid Induction of P/C-type Inactivation Is the Mechanism for Acid-induced K⁺ Current Inhibition

Uncoupling of Gating Charge Movement and Closure of the Ion Pore During Recovery from Inactivation in the Kv1.5 Channel

Altered State Dependence of C-Type Inactivation in the Long and Short Forms of Human Kv1.5

On the Mechanism by which 4-Aminopyridine Occludes Quinidine Block of the Cardiac K⁺ Channel, hKv1.5

Allosteric Effects of Permeating Cations on Gating Currents during K⁺ Channel Deactivation

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