Figure 1. VCF highlights the unique role of the sodium channel’s domain IV voltage sensor. (A) Membrane topology of a voltage-gated sodium ion channel. The location of the fluorescent probes on each of the S4s are highlighted using colored More about this image found in VCF highlights the unique role of the sodium channel’s domain IV voltage se...

Figure 1. Relationship between maximal speed of shortening and actin-activated ATPase activities measured in skeletal and smooth muscles from a variety of mammalian species. The data plotted here were taken from Table IV in article by Bárány More about this image found in Relationship between maximal speed of shortening and actin-activated ATPase...

Figure 2. Drs. Michael and Kate Bárány upon joining the faculty of the University of Illinois School of Medicine, 1975. Photo provided by Dr. Francis Bárány. Figure 2. Drs. Michael and Kate Bárány upon joining the faculty of the University of More about this image found in Drs. Michael and Kate Bárány upon joining the faculty of the University of ...

Figure 3. Drs. Michael and Kate Bárány operating a Beckman Model E ultracentrifuge to determine protein molecular weights. Photo provided by Dr. R. John Solaro. Figure 3. Drs. Michael and Kate Bárány operating a Beckman Model E ultracentrifuge More about this image found in Drs. Michael and Kate Bárány operating a Beckman Model E ultracentrifuge to...

Figure 4. Dr. Michael Bárány as Emeritus Professor at UIC. Photo provided by Dr. R. John Solaro. Figure 4. Dr. Michael Bárány as Emeritus Professor at UIC. Photo provided by Dr. R. John Solaro. More about this image found in Dr. Michael Bárány as Emeritus Professor at UIC. Photo provided by Dr. R. ...

Figure 1. Morphological changes accompanying secretion are identified by EM. (A) Mucocyst discharge in the ciliated protist Tetrahymena pyriformis. A longitudinal section showing a cilium, its accompanying parasomal sac (ps), and a discharging More about this image found in Morphological changes accompanying secretion are identified by EM. (A) Muc...

Figure 2. Events associated with fusion in the planar bilayer assay. (A) Progression of events associated with fusion from left to right. A multilamellar vesicle is situated on the cis side of a planar bilayer. It contains ion-permeable channels More about this image found in Events associated with fusion in the planar bilayer assay. (A) Progression...

Figure 3. Fluorescence-based imaging of single-vesicle fusion. (A) Diagram of the fluorescence microscope arrangement and video equipment. The light sources, filters, dichroic mirror, objective, condenser, and eyepieces were components of an More about this image found in Fluorescence-based imaging of single-vesicle fusion. (A) Diagram of the fl...

Figure 1. The essentials of the PLM. The asymmetry in ion distributions between the cytoplasm and extracellular space is established by an NKA (top). The flexible membrane is permeable to Na⁺, K⁺, Cl⁻, and water. Impermeant molecules (X), mostly More about this image found in The essentials of the PLM. The asymmetry in ion distributions between the ...

Figure 2. The action of the NKA stabilizes cell volume. The line labeled “NKA on” indicates when the pump is turned on and then off (p = 0.5 μC cm⁻² s⁻¹). The composition of the extracellular solution is changed during the period indicated by More about this image found in The action of the NKA stabilizes cell volume. The line labeled “NKA on” in...

Figure 3. Constraints on the PLM. The steady-state intracellular ion concentrations ([Conc.], top), voltage (middle), and volume (bottom) are plotted as a function of the NKA pump rate (p). The concentrations are stacked as in Fig. 2 . The More about this image found in Constraints on the PLM. The steady-state intracellular ion concentrations ...

Figure 4. Joseph Hoffman (left) and Daniel Tosteson (right). Photograph from 1955 or 1956 at the Museum of National History, Frederiksborg Castle, Hillerød, Denmark, taken when Tosteson was a postdoctoral fellow in Hans Ussing’s laboratory in More about this image found in Joseph Hoffman (left) and Daniel Tosteson (right). Photograph from 1955 or...

Figure 4. Ca²⁺-dependent release of intracellular constituents from intact and permeabilized bovine adrenal chromaffin cells. (A) Ca²⁺-dependent release from intact bovine chromaffin cells in response to 500 µM of the cholinergic agonist More about this image found in Ca²⁺-dependent release of intracellular constituents from intact...

Figure 5. The role of inositol phospholipids in fusion. (A) PH-GFP identifies primarily PI(4,5)P₂ in the plasma membrane (note fluorescence in cell periphery; left panel). When a critical basic residue for the interaction is mutated, GFP does More about this image found in The role of inositol phospholipids in fusion. (A) PH-GFP identifies primar...

Figure 6. Heterogeneity of Ca²⁺ responses of cortical granules in the planar cortex assay. (A) Cortices treated with 0.1 µM Ca²⁺ (left panel) or 17 µM Ca²⁺ (right panel). Taken from Zimmerberg et al. (1985) , A is reprinted with permission from More about this image found in Heterogeneity of Ca²⁺ responses of cortical granules in the plan...

Figure 7. Patch-clamp electrophysiology enables real-time detection of granule fusion in mast cells. (A) A sketch of the exocytotic fusion pore that has resulted from fusion. Superimposed on the cartoon is the equivalent circuit. R_c and C_c, More about this image found in Patch-clamp electrophysiology enables real-time detection of granule fusion...