A collection of fundamental mechanistic insight into the function and dysfunction of excitatory synapses. Research covers the release and retrieval of synaptic vesicles; structure, function and pharmacology of glutamate receptors; and the cellular action of some common drugs.
Excitatory synapses are the primary means by which information is communicated from one region of the central nervous system to another. Dynamic changes to their structure and molecular composition are associated with functional changes that underlie experience-dependent plasticity. Correspondingly, disruption of excitatory synaptic function is associated with psychiatric disease, neurodegeneration, epilepsy and addiction.
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Image © 2019 Shi et al.