Relations are derived that describe the combined effects of electrodiffusion, the Na/K pump, and Na/Ca transport by carrier on the resting membrane potential. Equations are derived that apply to both steady-state and non-steady-state conditions. Some example calculations from the equations are plotted at different permeability coefficient ratios, PK:PCa:PNa. The equations predict a depolarizing action of Na/Ca transport when more than two Na ions per Ca ion are transported by the carrier. For all permeability ratios examined, a steady state for Ca ions is achieved with at most a few millivolts of depolarization.
Article| July 01 1980
Contribution of Na/Ca transport to the resting membrane potential.
R A Sjodin
Online Issn: 1540-7748
Print Issn: 0022-1295
J Gen Physiol (1980) 76 (1): 99–108.
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R A Sjodin; Contribution of Na/Ca transport to the resting membrane potential.. J Gen Physiol 1 July 1980; 76 (1): 99–108. doi: https://doi.org/10.1085/jgp.76.1.99
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