Various degrees of pharmacological K inactivation were induced by Cs or Ba in isolated single electroplaques of the electric eel. The resulting changes in K conductance give rise to very different steady-state current-voltage characteristics. They also induce differences in ion dynamics during spike electrogenesis. The dynamic changes were studied by AC bridge methods, registering the changes in impedance in synchrony with the neurally or directly evoked spikes. While spike electrogenesis was virtually unaffected by addition of Cs or Ba, the patterns of impedance changes were very different. The various patterns are accounted for by the changes in the respective current-voltage characteristics. The data constitute new evidence for regarding the electrically excitable component of the reactive membrane as a heterogeneous electrochemical system with separate and independently reactive channels that in the electroplaques are permselective for Na and K, respectively.
Article|
January 01 1970
Potassium Inactivation and Impedance Changes during Spike Electrogenesis in Eel Electroplaques
Francisco Ruiz-Manresa,
Francisco Ruiz-Manresa
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
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Adolfo C. Ruarte,
Adolfo C. Ruarte
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
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Tobias L. Schwartz,
Tobias L. Schwartz
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
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Harry Grundfest
Harry Grundfest
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
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Francisco Ruiz-Manresa
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Adolfo C. Ruarte
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Tobias L. Schwartz
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Harry Grundfest
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032, and the Marine Biological Laboratory, Woods Hole, Massachusetts 02543.
Dr. Ruarte's present address is Centro de Investigaciones Neurologicas, Instituto T. di Tella, Gallo 1330, Buenos Aires, Argentina. Dr. Schwartz' present address is Biological Sciences Group, University of Connecticut, Storrs, Connecticut 06268.
Received:
July 28 1969
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright © 1970 by The Rockefeller University Press
1970
J Gen Physiol (1970) 55 (1): 33–47.
Article history
Received:
July 28 1969
Citation
Francisco Ruiz-Manresa, Adolfo C. Ruarte, Tobias L. Schwartz, Harry Grundfest; Potassium Inactivation and Impedance Changes during Spike Electrogenesis in Eel Electroplaques . J Gen Physiol 1 January 1970; 55 (1): 33–47. doi: https://doi.org/10.1085/jgp.55.1.33
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