The generator potential of both slowly and rapidly adapting crayfish stretch receptor cells can still be elicited by mechanical stimuli when all the Na of the bathing medium is replaced by various organic cations. In the presence of tris(hydroxymethyl)aminomethane (Tris), the generator potential is particularly large, about 30–50 % of that in the control saline, while spike electrogenesis of the cell is abolished. Persistence of the generator response is not due to retention of Na by a diffusion barrier, and ionic contributions to the electrogenesis by Ca and Cl can also be excluded. Thus, whereas the electrogenesis of the generator membrane must be due to an increased permeability to monovalent cations, the active receptor membrane appears to be less selective for different monovalent cations than is the receptor component of some other cells, or the conductile component of the stretch receptor neuron.
Article| August 01 1968
Effects of Some Organic Cations on Generator Potential of Crayfish Stretch Receptor
From the Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York 10032.
Dr. Obara's present address is Department of Anatomy, Albert Einstein College of Medicine, Bronx, New York 10461
Received: January 29 1968
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright © 1968 by The Rockefeller University Press
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Shosaku Obara; Effects of Some Organic Cations on Generator Potential of Crayfish Stretch Receptor . J Gen Physiol 1 August 1968; 52 (2): 363–386. doi: https://doi.org/10.1085/jgp.52.2.363
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