From the ability of a concentrated suspension of human erythrocytes to regulate the pH of unbuffered, anisotonic, external media it is possible to calculate the fractional cell volume in which chloride is dissolved. The difference between this volume and the total cell water gives the nonsolvent water (for chloride) of the cell. Nonsolvent water is less than 3% of the isotonic cell volume. The quantity of nonsolvent water per cell may increase as the cells shrink in hypertonic solutions.
Article| May 01 1967
Nonsolvent Water in Human Erythrocytes
John S. Cook
From the Department of Physiology and Biophysics, New York University Medical Center, New York.
Dr. Cook's present address is Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee
Received: July 11 1966
Online Issn: 1540-7748
Print Issn: 0022-1295
Copyright © 1967 by The Rockefeller University Press
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John S. Cook; Nonsolvent Water in Human Erythrocytes . J Gen Physiol 1 May 1967; 50 (5): 1311–1325. doi: https://doi.org/10.1085/jgp.50.5.1311
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