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Volume 46, Issue 6
1 July 1963
Journal of General Physiology Cover Image for Volume 46, Issue 6
Article| July 01 1963

Some Electrical Properties of a Nuclear Membrane Examined with a Microelectrode

Werner R. Loewenstein,
Werner R. Loewenstein
From the Department of Physiology, Columbia University, College of Physicians and Surgeons, New York. Dr. Kanno is on leave of absence from the Department of Physiology, Tokyo Medical and Dental University, Tokyo, Japan
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Yoshinobu Kanno
Yoshinobu Kanno
From the Department of Physiology, Columbia University, College of Physicians and Surgeons, New York. Dr. Kanno is on leave of absence from the Department of Physiology, Tokyo Medical and Dental University, Tokyo, Japan
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Author and Article Information
Werner R. Loewenstein
From the Department of Physiology, Columbia University, College of Physicians and Surgeons, New York. Dr. Kanno is on leave of absence from the Department of Physiology, Tokyo Medical and Dental University, Tokyo, Japan
Yoshinobu Kanno
From the Department of Physiology, Columbia University, College of Physicians and Surgeons, New York. Dr. Kanno is on leave of absence from the Department of Physiology, Tokyo Medical and Dental University, Tokyo, Japan
Received: January 14 1963
Online ISSN: 1540-7748
Print ISSN: 0022-1295
Copyright, 1963, by The Rockefeller Institute Press
1963
J Gen Physiol (1963) 46 (6): 1123–1140.
https://doi.org/10.1085/jgp.46.6.1123
Article history
Received:
January 14 1963

Electrical potential and resistance were measured with microelectrodes in in situ and isolated nuclei of gland cells of Drosophila flavorepleta. The nucleus-cytoplasm boundary was found to be rather impermeable to ion diffusion. It presents a resistance of the order of 1 Ω cm2 and sustains a "resting" potential, the nucleoplasm being about 15 mv negative with respect to the cytoplasm. Both the resistance and potential appear to be associated with the nuclear membrane: the potential declines to zero and the resistance to a fraction of its original value, when the membrane is perforated experimentally.

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Copyright, 1963, by The Rockefeller Institute Press
1963
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