1. Iodoacetate, fluoride, and azide have been found to prevent the formation of phage and to inhibit the synthesis of ATP by Staphylococcus muscae. It is suggested that energy-rich phosphate is needed for the synthesis of phage.
2. Gramicidin prevented the formation of phage.
3. No differences were found between normal bacteria and phage-infected bacteria in the inorganic phosphate, adenosinetriphosphate, ribonucleic acid, and desoxyribonucleic acid content of the cells.
4. The mechanism of phage formation is discussed.
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Copyright, 1947, by The Rockefeller Institute for Medical Research
1947
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