Vol. 158, No. 5 | https://doi.org/10.1085/jgp.202513923 | July 7, 2026.
The author regrets that, during final file preparation, the last row of Table 1 providing NCBI accession numbers for human data was mistakenly removed. Additionally, the accession numbers in the SCN2A column for hedgehog, guinea pig, and deer mouse have been updated. In the SCN3A column, the accession number for elephant has been deleted and replaced by “N.A.”
NCBI Accession numbers for entries in Table 2
In Table 2, in the European hedgehog row of the SCN2A Nav1.2A column, the mutation has been corrected to “L.” Also, the technical name for deer mouse, “Peromyscus maniculatus,” has been changed to “Peromyscus spp.” For the Norway rat Nav1.3A, “L” has been entered.
Prevalence of methionine-for-leucine substitution in TTX-sensitive v.g. Na channels of the hearts of hibernators
| Common name | Technical name | NQATX.., X = ? | |||||
|---|---|---|---|---|---|---|---|
| SCN1A Nav1.1A | SCN2A Nav1.2A | SCN3A Nav1.3A | SCN8A Nav1.6A | SCN4A Nav1.4A | Hibernator? | ||
| 13-Lined ground squirrel | Ictidomys tridecemlineatus | M | M | ______ | L | L | Yes |
| Arctic ground squirrel | Urocitellus parryii | M | M | L | L | L | Yes |
| Yellow-bellied marmot | Marmota flaviventris | M | M | ______ | L | L | Yes |
| Woodchuck or groundhog | Marmota monax | M | L | M | L | L | Yes |
| European marmot | Marmota marmota | M | L | ______ | L | L | Yes |
| Golden hamster | Mesocricetus auratus | L | L | ______ | L | L | Yes |
| European hedgehog | Erinaceus europeus | M | L | L | L | L | Yes |
| Little brown bat | Myotis lucifugus or myotis | M | M | L | L | M | Yes |
| Big brown bat | Eptesicus fuscus | M | M | ______ | L | M | Yes |
| Beaver | Castor canadensis | _____ | L | L | L | L | No |
| Guinea pig | Cavia porcellus | L | L | ______ | L | L | No |
| Deer mouse | Peromyscus spp. | L | L | ______ | L | L | No |
| Norway rat | Rattus norvegicus | L | L | L | L | L | No |
| E gray squirrel | Sciurus carolinensis | L | L | ______ | L | L | No |
| Rabbit | Oryctolagus cuniculus | ______ | L | ______ | L | L | No |
| Dog | Canis lupus familiaris | L | L | ______ | L | L | No |
| Shrew | Sorex araneus | L | L | ______ | L | L | No |
| Elephant | Loxodonta africanus | L | L | ______ | L | L | No |
| Horse | Equus caballus | L | L | L | L | L | No |
| Human | Homo sapiens | L | L | ______ | L | L | No |
The segment in which an M-for-L mutation is found is in the sixth transmembrane segment of domain one (DIS6) and begins NQAT in most Nav1s. (In Nav1.4, glutamate replaces glutamine, thus NEAT). Criteria for the selection of hibernators are provided in Materials and methods. Briefly, nonhibernators resist lowering of body temperature below 30°C in a cold environment by increasing heat production and insulation. Hibernators listed in the table in low ambient temperature and under appropriate circumstances, specific to the species, allow or even promote a decrease in core temperature to below 10°C and to as low as 0°C and regulate temperature and respiration at that low temperature for days or weeks. Dashed lines indicate that no sequence was available in the NCBI database. In the headings of each column, gene names are shown above protein identities.
The corrected tables are provided with the updated information in bold. The errors remain only in PDFs downloaded before August 28, 2026.
