Which Model Is Best? Let the Data Decide

The Perspectives on Ion Permeation center around the question of which approach is the most adequate in describing ion permeation. Obviously, one way to decide is to compare the outcome of the various models with experimental results and to let the range of validity and the model's ability of prediction be the major judge in grading models. An obstacle in doing so has been the lack of standards for electrophysiological recordings. A well-maintained, widely accepted, public database of raw data of current–voltage (IV) recordings and related measurements that, with time, becomes more complete will significantly improve the endeavor of finding realistic descriptions of ion permeation. The idea of a public database is old and databases for protein structures and gene sequences have proven very useful. They act as interfaces in highly multidisciplinary scientific communities. There is a similar need...